Simian immunodeficiency virus SIVagm.sab infection of Caribbean African green monkeys: a new model for the study of SIV pathogenesis in natural hosts.

Journal of Virology
Ivona PandreaRonald S Veazey

Abstract

Caribbean-born African green monkeys (AGMs) were classified as Chlorocebus sabaeus by cytochrome b sequencing. Guided by these phylogenetic analyses, we developed a new model for the study of simian immunodeficiency virus (SIV) infection in natural hosts by inoculating Caribbean AGMs with their species-specific SIVagm.sab. SIVagm.sab replicated efficiently in Caribbean AGM peripheral blood mononuclear cells in vitro. During SIVagm.sab primary infection of six Caribbean AGMs, the virus replicated at high levels, with peak viral loads (VLs) of 10(7) to 10(8) copies/ml occurring by day 8 to 10 postinfection (p.i.). Set-point values of up to 2 x 10(5) copies/ml were reached by day 42 p.i. and maintained throughout follow-up (through day 450 p.i.). CD4(+) T-cell counts in the blood showed a transient depletion at the peak of VL, and then returned to near preinfection values by day 28 p.i. and remained relatively stable during the chronic infection. Preservation of CD4 T cells was also found in lymph nodes (LNs) of chronic SIVagm.sab-infected Caribbean AGMs. No activation of CD4(+) T cells was detected in the periphery in SIV-infected Caribbean AGMs. These virological and immunological profiles from peripheral blood and LNs were iden...Continue Reading

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Citations

Apr 29, 2010·Current HIV/AIDS Reports·Ivona Pandrea, Cristian Apetrei
Nov 1, 2013·ILAR Journal·Anna J JasinskaNelson B Freimer
Apr 18, 2009·Current Opinion in HIV and AIDS·Jason M Brenchley, Daniel C Douek
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Mar 10, 2012·Science·Ann ChahroudiGuido Silvestri
Oct 17, 2006·Clinical Microbiology Reviews·Sue VandeWoude, Cristian Apetrei
Oct 15, 2008·Infection and Immunity·Cynthia A RossiElizabeth K Leffel
Jan 25, 2008·Journal of Virology·Ivona PandreaCristian Apetrei
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Sep 28, 2006·Blood·Ivona PandreaGuido Silvestri
Jan 26, 2013·PLoS Pathogens·Dongzhu MaUNKNOWN International Vervet Research Consortium
Mar 29, 2014·Immunogenetics·A AarninkA Blancher
May 20, 2014·The Journal of Clinical Investigation·Jan KristoffIvona Pandrea
Mar 16, 2007·Expert Opinion on Emerging Drugs·Emma J Bishop, Benjamin P Howden
Aug 13, 2008·Expert Opinion on Biological Therapy·L Jean Patterson, Marjorie Robert-Guroff
Aug 5, 2008·Trends in Immunology·Ivona PandreaCristian Apetrei
Jun 19, 2013·Immunological Reviews·Huanbin XuRonald S Veazey

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