Simian parvovirus infection in cynomolgus monkey heart transplant recipients causes death related to severe anemia

Transplantation
Carsten SchröderM Gerard O'Sullivan

Abstract

Simian parvovirus (SPV) was first isolated from cynomolgus monkeys. Like human parvovirus B19, this virus has a predilection for erythroid cells. During acute SPV infection, clinical signs are usually mild or inapparent, but severe anemia may occur in immunocompromised animals. We report several cases of symptomatic SPV infection in cynomolgus monkeys following heart transplantation. Twenty-three consecutive abdominal heterotopic heart transplants were studied. Viremia, measured by dot blot and/or PCR, and SPV-specific antibodies were determined retrospectively. All except one animal were on an immunosuppressive protocol. In all, 48% (11/23) of transplant recipients had viremia with SPV detected at some point after transplant. An additional 22% seroconverted before or after transplant, and were asymptomatic without detectable SPV. Of the 11 acutely viremic animals, five were euthanized because of severe anemia attributed to SPV. The remaining 30% of the transplant recipients did not seroconvert and were asymptomatic. Of seven recipients of donor tissue from seropositive or viremic animals, five became viremic and three died with anemia. No immunosuppressive regimen was implicated in increased susceptibility; the one transplant ...Continue Reading

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Citations

Mar 26, 2010·The Journal of Clinical Investigation·Shahrooz S KelishadiRichard N Pierson
Mar 8, 2008·ILAR Journal·Vito G Sasseville, Richard W Diters
Mar 8, 2008·ILAR Journal·Lynn M Wachtman, Keith G Mansfield
Mar 8, 2008·ILAR Journal·Silke V HausteinStuart J Knechtle
Nov 17, 2009·Journal of Immunotoxicology·Vito G Sasseville, Keith G Mansfield
Sep 22, 2017·The Journal of Infectious Diseases·Maki KisoYoshihiro Kawaoka

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