Abstract
Serum antibodies are widely utilised as specific and sensitive markers of virus infections but they have been employed relatively infrequently in the investigation of simian virus 40 (SV40) as a human carcinogen. In the past few years, serological data have become available which allow an examination of whether SV40 is currently circulating in human communities and if SV40 infection is associated with human cancer. The development of EIA with virus-like particles (VLPs) of SV40, BKV and JCV has facilitated serological studies. Sera from macaques naturally infected with SV40 cross-react unambiguously with BKV and JCV VLPs. Tests of over 9000 human sera with different immunological assays reveal a common pattern of SV40 reactivity. A small proportion of sera react at low titers and this reactivity is unrelated to age or the geographic location of the donor, but correlates with the presence and titers of BKV and JCV antibodies. Absorption with BKV and JCV VLPs decreases or abolishes the SV40 reactivity of human sera. The SV40 reactivity of sera from patients with mesothelioma, osteosarcoma or lymphomas, cancers which are reported to be associated with SV40, was similar to that in their controls or other comparison groups. The SV40...Continue Reading
Citations
Jul 27, 2007·Molecular Biotechnology·Massimiliano BergalloRossana Cavallo
Aug 10, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Adrienne L McNeesJanet S Butel
Jun 6, 2009·Journal of Clinical Microbiology·John A VanchiereJanet S Butel
Nov 14, 2006·Journal of Translational Medicine·Maurizio ProvenzanoGiulio C Spagnoli
Jul 21, 2005·Molecular Medicine·Valentina ParacchiniEmanuela Taioli
Jul 1, 2006·Cancer Investigation·Regis A Vilchez
Oct 6, 2005·Cancer Investigation·Eric A Engels
Jul 10, 2012·Current Opinion in Virology·Janet S Butel
May 22, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Annemarie ZieglerRolf A Stahel
Nov 8, 2014·Cancer·Elisa MazzoniMauro Tognon
Sep 4, 2012·The Journal of Infection·Connie WongJanet S Butel
Sep 16, 2008·Virology·Haruhiko MurataKeith Peden
Nov 11, 2008·Virology·Mengxi JiangMichael J Imperiale
Oct 22, 2014·PloS One·Manola ComarJanet S Butel
Nov 16, 2005·International Journal of Cancer. Journal International Du Cancer·Guri Olsen ThuTom Grotmol
Sep 12, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Danielle L Poulin, James A DeCaprio
Oct 27, 2018·Journal of Cellular Physiology·Elisa MazzoniManola Comar
Sep 28, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Regis A Vilchez, Shimon Kusne
Nov 30, 2006·International Journal of Cancer. Journal International Du Cancer·Keerti V Shah
May 14, 2005·Expert Review of Vaccines·Eric A Engels
Feb 23, 2007·International Journal of Cancer. Journal International Du Cancer·Kristina KjaerheimMichael Pawlita
Jul 6, 2013·American Journal of Industrial Medicine·Zohreh Mohammad-TaheriEugene Jerome Mark
Apr 5, 2005·Cancer Research·James J ManfrediStuart A Aaronson
Oct 8, 2013·ACS Chemical Biology·Stanislav KlerAdam Zlotnick