Simiao Decoction Alleviates Gouty Arthritis by Modulating Proinflammatory Cytokines and the Gut Ecosystem

Frontiers in Pharmacology
Xiaoying LinZhixing He

Abstract

Simiao decoction, a classical traditional Chinese medicine (TCM) formula, has been widely used for thousands of years due to its safety and efficiency in treating gouty arthritis. Utilizing serum proinflammatory cytokines and gut ecosystems, this study elucidated the mechanisms of alleviating gouty arthritis by Simiao decoction. Simiao decoction (4.0, 8.0, and 16.0 g/kg) was orally administered to gouty arthritis mice and febuxostat was given as a positive control. The spleen, kidney, and liver indexes indicated that Simiao decoction was safe for the treatment of gouty arthritis in C57BL/6 mice. Besides, our study demonstrated that Simiao decoction was effective for reducing the level of serum uric acid and decreasing MPO, XOD, and ADA activity, as well as alleviating gouty-related symptoms, such as foot swelling and pain. Moreover, Simiao decoction could also reduce some specific serum proinflammatory cytokines including IL-1β, IL-9, IFN-γ, MIP-1α and MIP-1β. We then surveyed the effects of Simiao decoction on the gut ecosystems in a systematic manner by combining network pharmacology, ELISA, western blot, and illumina sequencing. In the murine of model of gouty arthritis, Simiao decoction could suppress NLRP3 inflammasomes ex...Continue Reading

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Citations

Jan 23, 2021·Critical Reviews in Food Science and Nutrition·Jing WangFengqin Feng
Mar 28, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ruiting HanHoukai Li

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Datasets Mentioned

BETA
PRJNA557078
SRP216637

Methods Mentioned

BETA
ELISA
PCR
protein assay

Software Mentioned

Quantitative Insights into Microbial Ecology ( QIIME )
R
UCLUST
Bio
LEfSe
Miseq
Plex Manager Software
vegan
SPSS
STITCH

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