PMID: 11932197Apr 5, 2002Paper

Similar and divergent features in mammalian and yeast prions

Microbes and Infection
L Bousset, R Melki

Abstract

Mammalian transmissible spongiform encephalopathies are likely due to the propagation of an abnormal form of a constitutive protein instead of traditional genetic material (nucleic acids). Such infectious proteins, which are termed prions, exist in yeast. They are at the origin of a number of phenotypes that are inherited in a non-Mendelian manner. These prions are very useful to dissect the molecular events at the origin of this structure-based inheritance. The properties of mammalian and yeast prions are presented and compared. This review highlights a number of similarities and differences.

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Citations

Jun 6, 2007·Molecular and Cellular Biology·Elizabeth M H TankHeather L True
Mar 28, 2009·Journal of Molecular Biology·J Patrick Bardill, Heather L True
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