Similar antiviral efficacy and tolerability between efavirenz and lopinavir/ritonavir, administered with abacavir/lamivudine (Kivexa), in antiretroviral-naïve patients: a 48-week, multicentre, randomized study (Lake Study)

Antiviral Research
P EcheverríaBonaventura Clotet

Abstract

Although efavirenz and lopinavir/ritonavir(r) are both recommended antiretroviral agents in antiretroviral-naïve HIV-infected patients, there are few randomized comparisons of their efficacy and tolerability. A multicenter and randomized study was performed including 126 antiretroviral-naïve patients, randomly assigned to efavirenz+Kivexa (n=63) or lopinavir/r+Kivexa (n=63). Efficacy endpoints were the percentage of patients with HIV-RNA < or =50 copies/mL at week 48 and CD4 recovery. Safety was assessed by comparing toxicity and discontinuations. Statistical analyses were performed on an intention-to-treat (ITT) basis (Missing=Failure). At week 48, 56.7% of patients in the efavirenz and 63.2% in the lopinavir/r groups showed HIV-1 RNA <50 copies/mL (P=0.770) (intention-to-treat analysis; Missing=Failure). Only 1 (1.53%) patient from each group experienced virological failure. CD4 values increased in both groups (298 cells in the efavirenz group, P=0.001; 249 cells in the lopinavir/r group, P=0.002; P=0.126 between groups). HDL-cholesterol only increased in the efavirenz group (from 39+/-12 mg/dL to 49+/-11; P=0.001). Discontinuations were more frequent in the lopinavir/r group (36.5% versus 28.5%; P=0.193), but more patients w...Continue Reading

References

May 21, 2005·AIDS·Elizabeth J PhillipsNeil H Shear
Jun 28, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Clotilde AllavenaUNKNOWN Bitherapy Kaletra-Sustiva Study Group
May 16, 2008·The New England Journal of Medicine·Sharon A RiddlerUNKNOWN AIDS Clinical Trials Group Study A5142 Team

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Citations

Apr 17, 2012·International Journal of Hepatology·Manuela G NeumanCharles Parry
Sep 17, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C TortiI Frank
Apr 20, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Álvaro H BorgesJens D Lundgren
Dec 15, 2015·PloS One·Nicole Hassoun
Dec 1, 2011·The Journal of Antimicrobial Chemotherapy·José A Pérez-MolinaSantiago Moreno

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