Similar anxiety-like responses in male and female rats exposed to repeated withdrawals from ethanol

Pharmacology, Biochemistry, and Behavior
David H OverstreetGeorge R Breese

Abstract

Previous research indicated that male rats exhibited anxiety-like behavior following withdrawal from chronic ethanol exposure. This behavior, as well as other symptoms of withdrawal such as seizure susceptibility, may be sensitized in male rats repeatedly withdrawn from chronic ethanol exposure. Because there are sex differences in some alcohol effects, the present study explored whether male and female rats would respond differently to a course of repeated ethanol withdrawals. Similarly aged male and female rats were exposed to a control liquid diet or a diet containing ethanol (7% w/v). Ethanol-exposed rats had only one 5-day cycle of exposure or three cycles, with 2 days of control diet (CD) between cycles. At 5 h after the final ethanol was removed, the rats were placed as same-sexed pairs in the social interaction test; approximately half of the rats were tested later in the elevated plus maze. Rats withdrawn from ethanol after three cycles exhibited reduced the time spent in social interaction and general activity in the social interaction test and reduced the open and closed arm entries in the elevated plus maze. There were no sex differences in these effects. However, male rats exhibited a small anxiety-like response af...Continue Reading

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Citations

Mar 15, 2005·Psychopharmacology·George R BreeseDarin J Knapp
Jan 17, 2016·Pharmacological Reviews·Jill B Becker, George F Koob
Jan 2, 2016·Pharmacological Reviews·Styliani GoulopoulouR Clinton Webb
May 27, 2008·Pharmacology, Biochemistry, and Behavior·Nicholas W GilpinGeorge F Koob
Oct 24, 2007·Alcoholism, Clinical and Experimental Research·Mei SongLin Lu
Sep 1, 2007·Alcoholism, Clinical and Experimental Research·Tamara L Doremus-Fitzwater, Linda P Spear
Dec 24, 2009·Alcoholism, Clinical and Experimental Research·Simone BraconiRoberto Ciccocioppo
Sep 11, 2009·Alcoholism, Clinical and Experimental Research·Nicholas W GilpinHeather N Richardson
Apr 30, 2011·Pharmacology, Biochemistry, and Behavior·José R CriadoAleksander A Mathé
Sep 15, 2016·Alcohol·Nicholas J JuryAndrew Holmes
Mar 3, 2007·Journal of Psychopharmacology·David H Overstreet
Apr 25, 2018·Alcoholism, Clinical and Experimental Research·Harpreet SidhuCandice Contet
Nov 16, 2018·Alcoholism, Clinical and Experimental Research·Elizabeth A SneddonAnna K Radke
Dec 20, 2018·Alcoholism, Clinical and Experimental Research·Weston FlemingCynthia Kuhn
Jul 1, 2010·Alcoholism, Clinical and Experimental Research·Tiffany A WillsGeorge R Breese
Feb 27, 2020·Molecular Psychiatry·Daniel W BloodgoodThomas L Kash
Jun 3, 2011·Alcoholism, Clinical and Experimental Research·Lara S HwaKlaus A Miczek
Jun 25, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Natalie M ZahrAdolf Pfefferbaum
Feb 14, 2007·Alcoholism, Clinical and Experimental Research·L M VeatchC L Randall

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