Similar effect of intermittent theta burst and sham stimulation on corticospinal excitability: A 5-day repeated sessions study

The European Journal of Neuroscience
Ruben Perellón-AlfonsoMaja Kojovic

Abstract

Despite accumulating evidence of inter and intraindividual variability in response to theta burst stimulation, it is widely believed that in therapeutic applications, repeated sessions can have a "build-up" effect that increases the response over and above that seen in a single session. However, strong evidence for this is lacking. Therefore, we examined whether daily administration of intermittent theta burst stimulation (iTBS) over the primary motor cortex induces cumulative changes in transcranial magnetic stimulation measures of cortical excitability, above the changes induced by sham stimulation. Over five consecutive days, 20 healthy participants received either active iTBS or sham stimulation. Each day, baseline measures of cortical excitability were assessed before and up to 30 min after the intervention. There was no significant difference in the rate of response between iTBS and sham stimulation on any of the 5 days. There was no iTBS specific cumulative increase of corticospinal excitability. The likelihood that an individual would remain a responder from day-to-day was low in both groups, implying high within-subject variability of both active and sham iTBS after-effects. In contrast, we found a high within-subject ...Continue Reading

References

Nov 1, 1993·The Journal of Physiology·T KujiraiC D Marsden
Feb 22, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M SommerW Paulus
Jan 25, 2005·Neuron·Ying-Zu HuangJohn C Rothwell
Jan 16, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Eman M KhedrAhmed Hamdy
Mar 21, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ying-Zu HuangHsin-Yi Wen
Aug 15, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martin V SaleMichael A Nordstrom
Aug 30, 2008·Journal of Neurophysiology·Ennio IezziAlfredo Berardelli
Jan 13, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hartwig Roman Siebner
Jul 2, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Fabrizio BenedettiAntonella Pollo
Jan 1, 2008·Brain Stimulation·Ulf Ziemann, Hartwig R Siebner
Jun 5, 2012·Cerebral Cortex·Masashi HamadaJohn C Rothwell
Nov 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Julia B PitcherMichael C Ridding
Jan 19, 2013·Neuroscience Letters·Kathrin Hoppenrath, Klaus Funke
Jan 24, 2013·Restorative Neurology and Neuroscience·Teresa Jacobson KimberleyHartwig R Siebner
Aug 13, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marine VernetAlvaro Pascual-Leone
Mar 19, 2014·Brain Stimulation·Virginia López-AlonsoMiguel Fernández-Del-Olmo
May 16, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Charlotte NettekovenChristian Grefkes
May 17, 2014·Brain : a Journal of Neurology·Zafiris J Daskalakis
Jul 19, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurLuis Garcia-Larrea
Mar 15, 2015·Frontiers in Psychology·Felix Duecker, Alexander T Sack
Sep 28, 2015·Restorative Neurology and Neuroscience·Min Su KimYun-Hee Kim
Feb 7, 2016·Neuroscience and Biobehavioral Reviews·Sung Wook ChungPaul B Fitzgerald
Jun 23, 2016·Journal of Chiropractic Medicine·Terry K Koo, Mae Y Li

❮ Previous
Next ❯

Citations

Oct 12, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Kaja KolmancicMaja Kojovic
Jan 1, 2019·PeerJ·Yekta AnsariFrançois Tremblay
Feb 23, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Adam MederUlf Ziemann
Apr 24, 2021·Scientific Reports·Daniel M McCalleyColleen A Hanlon
Jan 9, 2022·Scientific Reports·Kilian Abellaneda-PérezDavid Bartrés-Faz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Charlotte NettekovenChristian Grefkes
Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Michele FrancaJohn C Rothwell
© 2022 Meta ULC. All rights reserved