Similar eicosapentaenoic acid and docosahexaenoic acid plasma levels achieved with fish oil or krill oil in a randomized double-blind four-week bioavailability study

Lipids in Health and Disease
Karin Yurko-MauroNorman Salem

Abstract

Long-chain n-3 polyunsaturated fatty acids (LC n-3-PUFA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) provide multiple health benefits for heart, brain and eyes. However, consumption of fatty fish, the main source of LC n-3-PUFAs is low in Western countries. Intakes of LC n-3-PUFA can be increased by taking dietary supplements, such as fish oil, algal oil, or krill oil. Recently, conflicting information was published on the relative bioavailability of these omega-3 supplements. A few studies suggested that the phospholipid form (krill) is better absorbed than the fish oil ethyl ester (EE) or triglyceride (TG) forms. Yet studies did not match the doses administered nor the concentrations of DHA and EPA per supplement across such comparisons, leading to questionable conclusions. This study was designed to compare the oral bioavailability of the same dose of both EPA and DHA in fish oil-EE vs. fish oil-TG vs. krill oil in plasma at the end of a four-week supplementation. Sixty-six healthy adults (n = 22/arm) were enrolled in a double blind, randomized, three-treatment, multi-dose, parallel study. Subjects were supplemented with a 1.3 g/d dose of EPA + DHA (approximately 816 mg/d EPA + 522 mg/d DHA, regardless of for...Continue Reading

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Aug 27, 2014·Lipids in Health and Disease·Norman Salem, Connye N Kuratko
Mar 19, 2015·PloS One·Karin Yurko-MauroMary E Van Elswyk

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Citations

Oct 6, 2015·Marine Drugs·Elena TaleroVirginia Motilva
May 3, 2016·The Journal of Nutritional Biochemistry·Alex P KitsonRichard P Bazinet
May 29, 2016·Regulatory Toxicology and Pharmacology : RTP·Kurt S TandeBarry S Lynch
Mar 7, 2018·Scientific Reports·M Carmen CrespoFrancesco Visioli
Jan 29, 2019·The British Journal of Nutrition·Renate H M de GrootBarbara J Meyer
Apr 27, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anuran ChatterjeeMichael S Conte
Sep 1, 2017·Scientific Reports·Hidetoshi YamadaTakuji Okumura
Mar 10, 2018·Adipocyte·Jens LundLotte Lauritzen
Dec 16, 2020·Comprehensive Reviews in Food Science and Food Safety·Mirja Kaizer AhmmedAlaa El-Din Bekhit
May 28, 2021·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Reinhard Waehler

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BETA
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SAS®
IntegReview

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