Similar expression of oxidative genes after interval and continuous exercise

Medicine and Science in Sports and Exercise
Li WangKent Sahlin

Abstract

There is a debate whether interval or traditional endurance training is the most effective stimulus of mitochondrial biogenesis. Here, we compared the effects of acute interval exercise (IE) or continuous exercise (CE) on the muscle messenger RNA (mRNA) content for several genes involved in mitochondrial biogenesis and lipid metabolism. Nine sedentary subjects cycled for 90 min with two protocols: CE (at 67% VO2max) and IE (12 s at 120% and 18 s at 20% of VO2max). The duration of exercise and work performed with CE and IE was identical. Muscle biopsies were taken before and 3 h after exercise. There were no significant differences between the two exercise protocols in the increases in VO2 and HR, the reduction in muscle glycogen (35%-40% with both protocols) or the changes in blood metabolites (lactate, glucose, and fatty acids). The mRNA content for major regulators of mitochondrial biogenesis [peroxisome proliferator-activated receptor (PPAR) gamma coactivator 1alpha (PGC-1alpha), PGC-1-related coactivator, PPARbeta/delta] and of lipid metabolism [pyruvate dehydrogenase kinase isozyme 4 (PDK4)] increased after exercise, but there was no significant difference between IE and CE. However, the mRNA content for several downstream...Continue Reading

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Citations

Jun 24, 2010·European Journal of Applied Physiology·Niklas PsilanderKent Sahlin
Oct 12, 2012·European Journal of Applied Physiology·Niklas PsilanderKent Sahlin
Oct 18, 2016·The Journal of Physiology·Martin J MacInnis, Martin J Gibala
Sep 6, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Adam J TrewinNigel K Stepto
Jan 1, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Christopher P HedgesAnthony J R Hickey
Dec 28, 2012·American Journal of Physiology. Endocrinology and Metabolism·Per FrankKent Sahlin
May 2, 2013·American Journal of Physiology. Endocrinology and Metabolism·William ApróKent Sahlin
Apr 29, 2015·Molecular and Cellular Biochemistry·L Mille-HamardV L Billat
Jun 5, 2021·Scientific Reports·Marie HagmanMuhammad Asghar

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