PMID: 6969374Dec 1, 1980Paper

Similar kinetic characteristics of 5-hydroxytryptamine binding in blood platelets and brain membranes of rats

Neuroscience Letters
H P Von HahnA Pletscher

Abstract

Blood platelets and brain membranes of SIV and Lewis rats both exhibited two saturable binding sites for 5-hydroxytryptamine (5-HT) in the concentration range 1-100 nM. The Kd values for the high-affinity sites were 4-6 nM and for the low-affinity sites 20-40 nM in both tissues of both rat strains. Blood platelets had 100-200 times more binding sites per mg protein (Bmax) than brain membranes. Thus, 5-HT receptors of platelets may be used as models for those of cerebral 5-HT-neurons.

Citations

Jan 1, 1983·Journal of Neural Transmission·A Pletscher, H Affolter
Jan 1, 1982·Journal of Neural Transmission·E DehlinB Winblad
Jan 1, 1985·Journal of Neural Transmission·D Hoffmann, W Wesemann
Sep 15, 1985·Thrombosis Research·W Wesemann, D Hoffmann
Jan 1, 1989·Psychiatry Research·C S BrownR M Rose
Apr 9, 1998·Biological Psychiatry·T E MoffittP Silva
Jun 28, 2003·Neurotoxicity Research·Claudio A NaranjoLescia K Tremblay
Jun 6, 2012·Biochimica Et Biophysica Acta·Tapan AudhyaLeah Johansen
Jan 1, 1990·Acta Psychiatrica Scandinavica·D BaillyP J Parquet
Dec 12, 2012·New Directions for Child and Adolescent Development·Kazumi Sugimura, Shinichi Mizokami
Sep 2, 2000·Neuroscience and Behavioral Physiology·N N Kudryavtseva

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