PMID: 9639682Jun 26, 1998Paper

Similar mutational spectra in the HPRT gene of human and hamster cell lines after exposure to either low dose rate or high dose rate X-rays

Mutation Research
N ColussiP H Lohman

Abstract

The dose rate at which cells are exposed to X-rays may influence the nature of induced mutations. To investigate this, the molecular spectra were determined at the HPRT gene in a hamster (V79) and a human (WI-L2-NS) cell line after the same total dose of X-rays has been administered at either a low dose rate (LDR; 3.33 mGy/min) or a high dose rate (HDR; 1.24-1.4 Gy/min) X-irradiation. Mutational spectra appeared similar, the fraction of mutants carrying deletions ranging between 59%-66% for the V79 strain and between 64%-75% for the WI-L2-NS strain, and independent of the irradiation conditions. The data indicate no effect of ongoing repair processes under LDR conditions on the kind of induced mutations in mammalian cells.

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Citations

Feb 2, 2013·Public Health Nutrition·Fernanda Serra GranadoUNKNOWN ACTION Study Team
Nov 1, 2012·Public Health Nutrition·Mercedes de OnisJuan Brines
May 23, 2008·Radiation Research·Kai RothkammMarkus Löbrich
May 31, 2018·Environmental Pollution·Edward J Calabrese

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