Similar recovery of liver function after response to all-oral HCV therapy in patients with cirrhosis with and without HIV coinfection

Journal of Viral Hepatitis
Juan MacíasHEPAVIR GEHEP, RIS-HEP07 study groups

Abstract

Among patients with cirrhosis, recovery of liver function after SVR to all-oral direct-acting antivirals (DAA) in HIV/HCV coinfection could be different to that in HCV monoinfection. Because of this, we compared the changes in several markers of liver function between HCV-monoinfected and HIV/HCV-coinfected patients with cirrhosis who achieved SVR12 to DAA combinations. In this retrospective cohort study, cirrhotics included in the HEPAVIR-DAA and GEHEP-MONO cohorts were selected if they had SVR12 to all-oral DAAs. Patients treated with atazanavir were excluded. Liver function improvement was defined as Child-Pugh-Turcotte (CPT) decrease ≥1 and/or MELD decrease ≥2 between baseline and SVR12. Liver function worsening was defined as a CPT increase ≥1 and/or MELD increase ≥2 and/or decompensations between baseline and SVR12. We included 490 patients, 270 (55%) of them with HIV coinfection. Liver function improved in 50 (56%) HCV-infected individuals and in 82 (57%) HIV/HCV-coinfected patients (P = 0.835). Liver function worsened in 33 (15%) HCV-monoinfected patients and in 33 (13%) HIV/HCV-coinfected patients (P = 0.370). Factors independently related with liver function improvement were male gender [adjusted OR (AOR) 2.1 (95% con...Continue Reading

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Citations

Sep 11, 2018·Journal of Viral Hepatitis·Juan MacíasUNKNOWN the HEPAVIR, GEHEP and RIS-HEP07 study groups
Jan 16, 2022·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ana Virseda-BerdicesUNKNOWN ESCORIAL Study Group

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