Similar withdrawal severity in adolescents and adults in a rat model of alcohol dependence.

Alcohol
Stephanie A MorrisK Nixon

Abstract

Alcohol use during adolescence leads to increased risk of developing an alcohol use disorder (AUD) during adulthood. Converging evidence suggests that this period of enhanced vulnerability for developing an AUD may be due to the adolescent's unique sensitivity and response to alcohol. Adolescent rats have been shown to be less sensitive to alcohol intoxication and withdrawal susceptibility; however, age differences in ethanol pharmacokinetics may underlie these effects. Therefore, this study investigated alcohol intoxication behavior and withdrawal severity using a modified Majchrowicz model of alcohol dependence that has been shown to result in similar blood ethanol concentrations (BECs) despite age differences. Adolescent (postnatal day, PND, 35) and adult rats (PND 70+) received ethanol according to this 4-day binge paradigm and were observed for withdrawal behavior for 17h. As expected, adolescents showed decreased sensitivity to alcohol-induced CNS depression as evidenced by significantly lower intoxication scores. Thus, adolescents received significantly more ethanol each day (12.3+/-0.1g/kg/day) than adults (9.2+/-0.2g/kg/day). Despite greater ethanol dosing in adolescent rats, both adolescent and adult groups had compar...Continue Reading

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Citations

Mar 13, 2010·Current Opinion in Psychiatry·Kimberly Nixon, Justin A McClain
May 28, 2011·Reviews in the Neurosciences·Adam StewartAllan V Kalueff
Mar 10, 2012·American Journal of Public Health·Maria Yellow Horse Brave HeartMelina Salvador
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Jul 13, 2013·Addiction Biology·Justin A McClainKimberly Nixon
Jan 26, 2013·Alcoholism, Clinical and Experimental Research·Dayna M HayesKimberly Nixon
Jan 5, 2016·Alcoholism, Clinical and Experimental Research·Justin A McClain, Kimberly Nixon
Apr 13, 2011·The Journal of Comparative Neurology·Justin A McClainKimberly Nixon
Sep 10, 2020·Frontiers in Neuroanatomy·S Alex MarshallKimberly Nixon
Nov 10, 2020·Alcoholism, Clinical and Experimental Research·Hui Peng, Kimberly Nixon
May 1, 2021·Brain Sciences·Natalie N NawarawongKimberly Nixon
Sep 7, 2021·Alcoholism, Clinical and Experimental Research·Jennifer K MelbourneKimberly Nixon

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