PMID: 6840684May 1, 1983Paper

Similarities and differences between models of extrahepatic biliary obstruction and complete biliary retention without obstruction in the rat

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
W G HardisonK Miyai

Abstract

Biliary obstruction in the rat causes known biochemical and morphological abnormalities. These abnormalities might be caused simply by retention of biliary constituents or might require other factors such as high biliary pressure, interruption of the normal flux of fluid, ions, and other biliary constituents through the hepatocyte and/or changes in intracellular concentrations, binding, and distribution of biliary constituents. We studied a choledochocaval (CC) fistula rat model characterized by complete biliary retention without bile stasis. CC fistula animals were compared with biliary obstructed rats over a 46-hr period. Bile flow and bile acid excretion rate reached high levels by hour 5 and remained high in CC fistula rats. Urinary bile acid excretion, shrinkage of the rapidly exchangeable bile acid pool, and serum bile acid and bilirubin concentrations were equivalent in the two models. Serum cholesterol concentration was higher and serum alkaline phosphatase and 5'-nucleotidase activities lower in obstructed rats. The percentage of beta-muricholate rose and the percentage of cholate decreased in bile acid from obstructed rats. This was associated with increased microsomal 6 beta-hydroxylase activity. Bile acid compositio...Continue Reading

References

Aug 1, 1979·European Journal of Clinical Investigation·J P BlomhoffE Gjone
Sep 1, 1977·The Journal of Clinical Investigation·R Galeazzi, N B Javitt
Dec 1, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·G P Van Berge Henegouwen, A F Hofmann
Apr 1, 1973·The Journal of Clinical Investigation·F R Simon, I M Arias
Feb 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·F HuttererH Popper
Jan 1, 1972·The American Journal of Physiology·W G Hardison, J T Apter
Jul 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D E Hatoff, W G Hardison
Aug 1, 1954·The Biochemical Journal·R K MORTON
Dec 1, 1960·The American Journal of Physiology·N R DI LUZIO, D B ZILVERSMIT
Nov 1, 1962·Clinica Chimica Acta; International Journal of Clinical Chemistry·A P WEBER, L SCHALM

❮ Previous
Next ❯

Citations

Mar 17, 2000·Journal of Gastroenterology and Hepatology·F KimuraK Nakagawa
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·E O SoutoG J Gores
Dec 1, 1993·European Journal of Clinical Investigation·E JacqueminS Erlinger
Nov 1, 1996·Digestive Diseases and Sciences·L SpahrG Pomier-Layrargues
May 23, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hernán E GonzálezJuan C Sáez
Jul 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L AccatinoC S Koenig
Mar 1, 1993·Clinical and Experimental Pharmacology & Physiology·M P PanozzoR Naccarato
Oct 1, 1989·British Journal of Pharmacology·H KotakeH Mashiba
Apr 17, 2003·The Journal of Surgical Research·Ulrich BaumgartnerChristian Ihling

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.