PMID: 2118203Jul 4, 1990Paper

Similarities and differences in progesterone and androgens in modulation of LH, FSH and PRL release: unexpected properties of flutamide

Journal of Steroid Biochemistry
D W BrannV B Mahesh

Abstract

The purpose of this study was to determine if the similarity of effect of progesterone and androgens on antagonism of estrogen-induced prolactin release also applied to the regulation of LH and FSH release. An additional objective was to examine the effect of the antiandrogen, flutamide, upon the ability of progesterone to induce gonadotropin secretion. Using the ovariectomized estrogen-primed immature rat, testosterone propionate suppressed LH and FSH secretion, whereas dihydrotestosterone only suppressed serum LH levels. In contrast, progesterone significantly elevated both serum LH and FSH levels. Thus, with respect to regulation of gonadotropin secretion, the effects of androgens and progesterone were dissimilar. In the estrogen-primed ovariectomized immature rat, flutamide was found to suppress LH, FSH and PRL secretion. Progesterone (0.8 mg/kg body wt) was incapable of overcoming this suppressive effect of flutamide. The effect of flutamide on gonadotropin secretion required estrogen priming. The effect of flutamide in suppressing LH, FSH and PRL release was not through suppression of an adrenal steroid as shown by adrenalectomy or the use of RU486. In the PMSG primed immature rat, flutamide had no effect on basal gonadot...Continue Reading

References

Mar 1, 1990·Proceedings of the Society for Experimental Biology and Medicine·D W BrannV B Mahesh
Jun 1, 1989·Biology of Reproduction·D W BrannV B Mahesh
Dec 1, 1988·Biology of Reproduction·D W BrannV B Mahesh
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·V B Mahesh
Apr 1, 1980·Acta Endocrinologica·J J PelusoR W Steger

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Citations

Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·G BoccuzziO Danni
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·M Di MonacoG Boccuzzi
Apr 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·M BicíkováL Stárka
Aug 26, 1998·The Journal of Steroid Biochemistry and Molecular Biology·M E Wilson, R J Handa
Jan 21, 2003·Biology of Reproduction·Ann S ClarkAndrew C Whitney
Oct 27, 2011·American Journal of Physiology. Endocrinology and Metabolism·Virendra B Mahesh

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