PMID: 2497491Jan 1, 1989Paper

Similarities between the stimulus properties of phenylpropanolamine and amphetamine

Psychopharmacology
F LeeB G Hoebel

Abstract

Rats at 80% body weight were trained to discriminate 1.0 mg/kg d-amphetamine versus saline in a two-lever, discrete trial drug discrimination task to obtain food pellets. After reliable discriminative control of lever choice was established, various doses of d,l-phenylpropanolamine (PPA, i.e., d,l-norephedrine) were substituted for the amphetamine training dose in non-reinforced test trials. Test doses of 10, 20, and 40 mg/kg PPA resulted in over 90% responses on the amphetamine-appropriate lever. Lower doses (1.25, 2.5, and 5.0 mg/kg) resulted in predominantly saline-appropriate responses. The generalization seen after the 20 mg/kg dose of phenylpropanolamine was blocked by pretreatment with 0.5 mg/kg haloperidol, suggesting that the generalization from amphetamine to PPA was mediated by a dopaminergic mechanism.

Citations

Dec 1, 1989·Pharmacology, Biochemistry, and Behavior·M Rosofsky, N Geary
Feb 1, 1990·Pharmacology, Biochemistry, and Behavior·P J Wellman
Jul 19, 2000·Pharmacology, Biochemistry, and Behavior·R Young, R A Glennon
Sep 17, 1998·Pharmacology, Biochemistry, and Behavior·R YoungR A Glennon
Jan 5, 2000·Drug and Alcohol Dependence·R YoungR A Glennon
Jan 26, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karen K SzumlinskiKevin D Lominac
Mar 12, 2008·Addiction Biology·Jeffery H PenznerKaren K Szumlinski

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