Similarities in cellular expression and functions of melanin-concentrating hormone and atrial natriuretic factor in the rat digestive tract

Endocrinology
G HervieuJ L Nahon

Abstract

Melanin-concentrating hormone (MCH) is a cyclic peptide isolated first from salmon brain, then from rat and human hypothalamus. We have recently found expression of MCH messenger RNA and encoded peptides, e.g. MCH and neuropeptide-glutamic acid-isoleucine, within the rat gastrointestinal (GI) tract, but their cellular origin was unclear. Furthermore, similarities in the localization of rat atrial natriuretic factor (ANF) and rat MCH immunoreactivities within intestine suggested functional convergence. In the present study we determined first the presence and distribution of MCH messenger RNA and encoded peptides in the GI tract by combining in situ hybridization and immunohistochemical analysis. Our data revealed numerous MCH-containing cells located in the lamina propria and submucosa at both duodenal and colonic levels. Second, the localisation of MCH- and arginine vasopressin- or ANF-containing cells appears similar at the duodenal and colonic levels, respectively. Colocalization of MCH/neuropeptide-glutamic acid-isoleucine immunoreactivity (-IR) and catecholamine indicated that MCH-expressing cells are probably antigen-presenting cells forming part of the enterochromaffin cell system. Third, we performed reverse phase HPLC ...Continue Reading

Citations

Jul 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Efi KokkotouCharalabos Pothoulakis
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·S AnK Dai
Sep 5, 1998·Brain Research·C L MillerR C Thompson
Jun 1, 2007·Regulatory Peptides·Bernard CoumansBernard Lakaye
Jul 30, 2003·Expert Opinion on Therapeutic Targets·Guillaume Hervieu
Mar 9, 2018·International Journal of Molecular Sciences·Rita KissZoltán Szilvássy
May 23, 2001·The Journal of Comparative Neurology·Y SaitoO Civelli
Sep 28, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Timothy J Kowalski, Thavalakulamgar Sasikumar
Mar 1, 2008·Nature Reviews. Drug Discovery·Gareth J Sanger, Kevin Lee
Feb 8, 2002·American Journal of Physiology. Cell Physiology·Terence ChiuEnrique Rozengurt
Mar 30, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dimitrios C ZiogasEfi Kokkotou
Jan 22, 1998·Biochemical and Biophysical Research Communications·J L BurgaudJ L Nahon
Aug 15, 2002·Biochemical and Biophysical Research Communications·Martin J HoogduijnAnthony J Thody

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