PMID: 6170069Jul 1, 1981Paper

Similarities in development of substance P and somatostatin in peripheral sensory neurons: effects of capsaicin and nerve growth factor

Proceedings of the National Academy of Sciences of the United States of America
J A Kessler, I B Black

Abstract

Development of the two putative peptide neurotransmitters, substance P (SP) and somatostatin (SS), were compared in rat dorsal root ganglion (DRG) and spinal cord in vivo. The content of SS in the sixth cervical DRG increased 5-fold during the first 5 weeks of life, rising from 24 pg per ganglion at birth. SP content increased 4.5-fold during the first 5 weeks, from 56 pg per ganglion at birth. The developmental profiles for these two peptides were virtually parallel, suggesting that their respective neuronal populations developed in synchrony. Treatment with nerve growth factor (NGF) significantly increased the content of both SP and SS in the DRG and dorsal spinal cord. Conversely, treatment with capsaicin significantly decreased both SP and SS in the DRG and dorsal spinal cord. Consequently, experiments involving NGF or capsaicin treatment of sensory neurons must be interpreted with extreme care, because specificity is not limited to a single peptide phenotype. Although the mechanisms of action of NGF and capsaicin on SP and SS have not been defined, the similarity of the responses of the two peptides suggests that their development may be regulated by similar processes.

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Citations

Feb 25, 2000·Journal of Neuroscience Research·J E Adler, P D Walker
Apr 1, 1984·Developmental Biology·J E AdlerI B Black
Jul 16, 1982·European Journal of Pharmacology·K TsouE L Way
May 31, 1982·Life Sciences·S H BuckT F Burks
Jul 1, 1982·Brain Research·S S Mohamed, M E Atkinson
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C S Ayer-LeLievre, A Seiger
Jun 6, 2003·Cytokine & Growth Factor Reviews·Shahrooz Rabizadeh, Dale E Bredesen
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M GoedertW Lichtensteiger
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H J MartínezI B Black
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A ChalazonitisS M Crain
May 1, 1994·International Journal of Dermatology·C PincelliA Giannetti
May 1, 1994·The Journal of Clinical Investigation·K KaralisG Tolis
Jan 1, 1988·The International Journal of Neuroscience·D G Payan, E J Goetzl
May 1, 1990·Experimental Neurology·J M LeeI B Black
Mar 1, 1984·Clinics in Endocrinology and Metabolism·W H Daughaday, E Heath
Sep 16, 2006·Developmental Biology·Pin Xu, Alison K Hall
Aug 10, 1999·Japanese Journal of Pharmacology·K KubotaK Saito

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