PMID: 8956381Nov 1, 1996Paper

Similarities in the pharmacology of spontaneous and DOI-induced head-shakes suggest 5HT2A receptors are active under physiological conditions

Psychopharmacology
S M Dursun, S L Handley

Abstract

Nine monoamine receptor antagonists have been compared for their potency to inhibit both spontaneously occurring and DOI ((1-)2,5-dimethoxy-4-iodophenyl)-2-aminopropane)-induced head-shakes (HS). Ritanserin, ketanserin, prazosin, haloperidol, pimozide, SCH 23390 and SCH 39166 potently and dose-dependently antagonised both types of HS while sulpiride and raclopride produced weak and partial antagonism. The potency of these agents to inhibit spontaneous HS and DOI-induced HS was closely correlated (r = 0.94) and was significantly related to 5HT2A receptor and to alpha 1-adrenoceptor affinities taken from published sources. Potency was independent of affinity for D2 receptors but there was a possible influence of D1 receptor affinity. HS have been proposed to model Tourette's Syndrome; thus the present findings may have implications for the mechanism of action of antipsychotic agents in this condition and possibly also in schizophrenia. Contrary to previous suggestions, 5HT2A receptors may be tonically activated under physiological conditions.

Citations

Jun 29, 2005·Psychopharmacology·William E FantegrossiJames H Woods
Feb 23, 2011·Psychopharmacology·John P Dougherty, Vincent J Aloyo
Dec 4, 2003·Pharmacology, Biochemistry, and Behavior·Renee L Hayslett, Yousef Tizabi
Mar 10, 2004·Pharmacology, Biochemistry, and Behavior·Kuldip D DaveVincent J Aloyo
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Kuldip D DaveVincent J Aloyo
Jul 25, 2003·Brain Research. Molecular Brain Research·Karin C WeissSabine P Cordes
Aug 22, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·Y TizabiN A Darmani
May 23, 2000·Drug Metabolism and Drug Interactions·L K Jaime, H Maharajh
Feb 5, 2016·Pharmacological Reviews·David E Nichols
Mar 31, 2007·Journal of Neurochemistry·Mercè Amargós-BoschFrancesc Artigas
Oct 13, 2004·European Journal of Pharmacology·Aminul IslamSheila L Handley
Nov 6, 2007·Biochemical Pharmacology·William E FantegrossiChad J Reissig
Jul 28, 2005·Pharmacology, Biochemistry, and Behavior·Renee L Hayslett, Yousef Tizabi
Apr 26, 2014·The International Journal of Neuropsychopharmacology·Hong-Yi ChiuHwei-Hsien Chen
Dec 1, 2012·The International Journal of Neuropsychopharmacology·Noemí SantanaFrancesc Artigas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here