PMID: 3770873Nov 1, 1986Paper

Similarities of essential and spontaneous hypertension. Volume and number of blood cells

Hypertension
G BruschiA Borghetti

Abstract

Spontaneously hypertensive rats have long been used as an animal counterpart of human essential hypertension. The validation of this strain as a model rests mainly on the "clinical" similarity of the two syndromes, but it has scarcely been founded on numerical comparison of measurable parameters. We investigated three hematological indexes previously recognized to be altered in spontaneously hypertensive rats: the single-cell volume of erythrocytes, the single-cell volume of platelets, and the erythrocyte number. Erythrocyte volume was lower by 7%, platelet volume was higher by 12%, and erythrocyte count was higher by 22% in spontaneously hypertensive rats in comparison with Wistar-Kyoto controls. More unexpectedly, it was found that erythrocyte volume is lower by 2%, platelet volume is higher by 3%, and erythrocyte number is higher by 6% in essential hypertensive subjects when compared with normotensive healthy subjects. These results, combined with previously reported blood cell alterations in subjects and rats, reinforce the evidence of a biological similarity between essential and spontaneous hypertension.

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Citations

Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J W BoylanP U Feig
Jun 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M PravenecE St Lezin
Oct 16, 2015·Bulletin of Experimental Biology and Medicine·A M AnishchenkoM B Plotnikov
May 1, 1996·Circulation·D S SharpK Yano
Jun 1, 1992·Hypertension·A Trzebski
Feb 1, 1992·Hypertension·M David-DufilhoM A Devynck
Sep 1, 1993·Biulleten' eksperimental'noĭ biologii i meditsiny·L A Mikhaĭlichenko
Apr 30, 2013·Environmental Monitoring and Assessment·Mohammad Reza GhotbiMohammad Hosein Gozashti
Jan 17, 2017·Bulletin of Experimental Biology and Medicine·M B PlotnikovE A Pushkina
Sep 9, 2020·Ecotoxicology and Environmental Safety·Tatjana TasićSilvio R De Luka

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