Similarity between the transcriptional silencer binding proteins ABF1 and RAP1

Science
J F Diffley, B Stillman

Abstract

The yeast ARS binding factor 1 (ABF1)--where ARS is an autonomously replicating sequence--and repressor/activator protein 1 (RAP1) have been implicated in DNA replication, transcriptional activation, and transcriptional silencing. The ABF1 gene was cloned and sequenced and shown to be essential for viability. The predicted amino acid sequence contains a novel sequence motif related to the zinc finger, and the ABF1 protein requires zinc and unmodified cysteine residues for sequence-specific DNA binding. Interestingly, ABF1 is extensively related to its counterpart, RAP1, and both proteins share a region of similarity with SAN1, a suppressor of certain SIR4 mutations, suggesting that this region may be involved in mediating SIR function at the silent mating type loci.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 1, 1987·Methods in Enzymology·M SnyderR W Davis
Jul 11, 1989·Nucleic Acids Research·J C DorsmanL A Grivell
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S X CaoA N Schechter
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T M NiedermanL Ratner
Jan 1, 1987·Cold Spring Harbor Symposia on Quantitative Biology·A Klug, D Rhodes
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W R Pearson, D J Lipman
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J F Diffley, B Stillman
Sep 4, 1987·Science·K Nasmyth, D Shore
Aug 25, 1987·Biochemistry·D P GiedrocJ E Coleman
Oct 5, 1984·Journal of Molecular Biology·J B FeldmanJ R Broach
Jan 1, 1983·Methods in Enzymology·R J Rothstein
Jan 1, 1983·Methods in Enzymology·M O DayhoffL T Hunt

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Citations

Sep 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·V Pirrotta
May 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C A Stanway
Jun 1, 1995·Journal of Cellular Biochemistry·M T RuizM Zannis-Hadjopoulos
Jan 13, 2010·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Christelle CayrouMarcel Méchali
Oct 8, 1991·Biochimica Et Biophysica Acta·L S KraakmanR J Planta
Nov 1, 1994·Trends in Genetics : TIG·D Shore
Mar 17, 2004·Biochimica Et Biophysica Acta·Nicholas L AdkinsPhilippe T Georgel
Mar 18, 2011·Molecular BioSystems·Sang Cheol Kim, Jung Kyoon Choi
Nov 3, 1998·Immunology and Cell Biology·S Dalton
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S S WalkerS Eisenberg
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S C Francesconi, S Eisenberg
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·H G EstesS Eisenberg
Nov 11, 2008·The Journal of Biological Chemistry·Shirong YuSimon H Reed
May 11, 1990·Nucleic Acids Research·Y A HenryS M Kingsman
May 11, 1992·Nucleic Acids Research·P M GonçalvesR J Planta
Apr 30, 2005·Nucleic Acids Research·Conrad A NieduszynskiAnne D Donaldson
Jul 2, 2003·Genes & Development·William M Fricke, Steven J Brill
Aug 2, 2006·FEMS Yeast Research·Lakshmi RamachandranWilliam C Burhans
May 28, 2013·Molekuliarnaia biologiia·T D Kolesnikova
Jun 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hao-Chi HsuRui-Ming Xu

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