Similarity of pharmacodynamic effects of a single injection of insulin glargine, insulin detemir and NPH insulin on glucose metabolism assessed by 24-h euglycaemic clamp studies in healthy humans

Diabetic Medicine : a Journal of the British Diabetic Association
L P SørensenO Schmitz

Abstract

Two long-acting insulin analogues, insulin glargine and insulin detemir, have been developed as alternatives to neutral protamine Hagedorn (NPH) insulin, which has been the preferred basal insulin preparation for decades. The aim was to directly compare the pharmacodynamic properties of the long-acting insulin analogues and NPH insulin after a single subcutaneous injection. The study was conducted as a double-blind, controlled, three-arm, crossover study including 10 healthy lean male volunteers. On three different occasions, each subject was challenged with 0.4 U kg(-1) of either insulin glargine, insulin detemir or NPH insulin. Plasma glucose was maintained at 0.3 mmol l(-1) below fasting level by glucose clamping for 24 h. C-peptide, insulin, free fatty acids (FFAs) and counter regulatory hormones were measured throughout the clamp period, whereas endogenous glucose release (EGR) was assessed by isotope dilution technique (3-(3)H-glucose). The mean glucose infusion rate (GIR)-time profiles revealed no significant differences between the three preparations in the primary endpoints: Maximal GIR of approximately 3.4 mg kg(-1) min(-1) (P = 0.68), time to maximal GIR of approximately 10 h (TR(max)) (P = 0.35) and area under the G...Continue Reading

References

Nov 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·O Hother-NielsenH Beck-Nielsen
Apr 29, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·L HeinemannT Heise
May 29, 2000·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·G A BrunnerT R Pieber
Oct 28, 2003·Diabetes Care·Matthew C RiddleUNKNOWN Insulin Glargine 4002 Study Investigators

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Citations

Jun 28, 2011·Diabetes Technology & Therapeutics·Francesca PorcellatiCarmine G Fanelli
Oct 30, 2014·Diabetes, Obesity & Metabolism·Allan Vaag
Apr 28, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity

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