PMID: 6261139Apr 2, 1981Paper

Similarity of teleocidin B and phorbol ester tumour promoters in effects on membrane receptors

Nature
K UmezawaT Sugimura

Abstract

The tumour promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and structurally related phorbol esters effect changes in avian and mammalian cell cultures that mimic transformation by oncogenic viruses or chemical carcinogens and the inhibition or induction of various types of differentiation (for review see refs 1--3). Unlike initiating carcinogens, which seem to act by binding covalently to cellular DNA, the primary site of action of the phorbol ester tumour promoters seems to be the cell membrane; indeed, specific high-affinity saturable receptors for phorbol esters have been identified in cell membranes. The recently discovered class of tumour promoters, the teleocidins, are as potent as TPA in the induction of ornithine decarboxylase in mouse skin, the inhibition of differentiation of Friend erythroleukaemia cells, the induction of HL-60 cell adhesion and the promotion of tumours on mouse skin. As the teleocidins are structurally unrelated to the phorbol esters, we set out to determine their effects on cell membranes and receptors. We found that in rodent cell cultures, teleocidin B and dihydroteleocidin B have effects similar to those of TPA and that, at nanomolar concentrations, teleocidin inhibits the binding of phorbo...Continue Reading

References

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Citations

Jan 1, 1984·Journal of Cancer Research and Clinical Oncology·H FujikiT Sugimura
Oct 1, 1986·Pflügers Archiv : European journal of physiology·C G CaratschF Eusebi
Nov 30, 1983·Biochemical and Biophysical Research Communications·S YamamotoR Kato
Apr 15, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·M KurobeK Hayashi
Jan 1, 1990·International Journal of Immunopharmacology·J FaveroJ W Parker
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·H FujikiR E Moore
Feb 23, 2011·Organic & Biomolecular Chemistry·Zhengren XuYanxing Jia
Sep 30, 1981·Biochemical and Biophysical Research Communications·S KumeT Oda
Aug 15, 1989·Biochemical and Biophysical Research Communications·J Heikkilä, K E Akerman
Feb 26, 1982·Biochemical and Biophysical Research Communications·M Collins, E Rozengurt
Mar 15, 1982·Biochemical and Biophysical Research Communications·K UmezawaT Takeuchi
Nov 1, 1992·Cytokine·M A DaytonD Benjamin
Jan 1, 1989·Japanese Journal of Cancer Research : Gann·K UmezawaT Takeuchi
Jan 1, 1983·Annals of the New York Academy of Sciences·P M BlumbergE Yeh
Jan 1, 1984·Journal of Cellular Physiology. Supplement·I B WeinsteinA Jeffrey
Jul 1, 1984·Journal of Cellular Physiology·A NovogrodskyK H Stenzel
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·I B Weinstein
Jul 31, 1985·Biochemical and Biophysical Research Communications·N IsakovA Altman
May 20, 2017·Pharmaceuticals·Marta RuiSimona Collina
Apr 1, 1983·Environmental Health Perspectives·H FujikiR E Moore
Oct 15, 1985·International Journal of Cancer. Journal International Du Cancer·A BalanaT Tursz
Jan 15, 1982·International Journal of Cancer. Journal International Du Cancer·D DeliaG Goldstein
Apr 15, 1983·International Journal of Cancer. Journal International Du Cancer·H HoshinoH Fujiki
Aug 15, 1981·International Journal of Cancer. Journal International Du Cancer·H YamamotoT Sugimura
Feb 15, 2011·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Maciej PowerskiIngo Marzi
Dec 15, 1982·International Journal of Cancer. Journal International Du Cancer·M PatarroyoG Klein

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