PMID: 6787651Jan 1, 1981

Similarity of the discriminative stimulus effects of ketamine, cyclazocine, and dextrorphan in the pigeon

S HerlingJ H Woods


Separate groups of pigeons were trained to discriminate the IM injection of ketamine, cyclazocine, or dextrorphan from saline. Each of the training drugs and phencyclidine produced dose-related, drug-appropriate responding in each group of birds. In contrast, ethylketazocine and nalorphine generally produced responding appropriate for saline. These results indicate that common elements of discriminable effects exist among ketamine, cyclazocine, and dextrorphan, structurally dissimilar compounds that are generally considered to belong to distinct pharmacological classes.


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Related Concepts

Discrimination Learning
Ketamine Hydrochloride
Phencyclidine Hydrobromide
Columba livia

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