Simple and effective method for producing [11C]phosgene using an environmental CCl4 gas detection tube

Nuclear Medicine and Biology
Masanao OgawaToshimitsu Fukumura

Abstract

Carbon-11-labeled phosgene is an important labeling precursor for PET molecular probes. Despite the usefulness of [(11)C]phosgene, some difficulties, especially in the formation of [(11)C]phosgene process from [(11)C]CCl(4), hamper its use. The present article shows a simple preparation method for [(11)C]phosgene. [(11)C]CCl(4) was obtained using the conventional method by passing a mixture of [(11)C]CH(4) and Cl(2) through a heated quartz tube. The [(11)C]CCl(4) was transformed to [(11)C]phosgene simply by passing through a pretreatment tube of a Kitagawa gas detection system for the working-environmental CCl(4) concentration measurement at room temperature with a flow rate of 50 ml/min. This tube successfully transformed [(11)C]CCl(4) to [(11)C]phosgene at room temperature. [(11)C]Phosgene was obtained at nearly 80% radiochemical yield (EOB) in a short synthesis time with high reproducibility. A high yield and reliable [(11)C]phosgene production method using a gas detector tube system for working-environmental CCl(4) concentration measurement was developed.

References

May 1, 2007·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·C Solbach, H-J Machulla

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Citations

Sep 22, 2010·Advanced Drug Delivery Reviews·Zibo Li, Peter S Conti
Apr 17, 2010·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Yuuki TakadaToshimitsu Fukumura
Nov 15, 2014·ACS Chemical Neuroscience·Katsushi KumataMing-Rong Zhang
Jan 30, 2020·Angewandte Chemie·Jimmy E JakobssonVictor W Pike
May 16, 2013·Chemical Communications : Chem Comm·Benjamin H RotsteinNeil Vasdev
Jun 18, 2020·Nuclear Medicine and Biology·Toshimitsu FukumuraMing-Rong Zhang

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