Simple and Objective Prediction of Survival in Patients with Lung Cancer: Staging the Host Systemic Inflammatory Response

Lung Cancer International
Derek GroseRobert Milroy

Abstract

Background. Prediction of survival in patients diagnosed with lung cancer remains problematical. The aim of the present study was to examine the clinical utility of an established objective marker of the systemic inflammatory response, the Glasgow Prognostic Score, as the basis of risk stratification in patients with lung cancer. Methods. Between 2005 and 2008 all newly diagnosed lung cancer patients coming through the multidisciplinary meetings (MDTs) of four Scottish centres were included in the study. The details of 882 patients with a confirmed new diagnosis of any subtype or stage of lung cancer were collected prospectively. Results. The median survival was 5.6 months (IQR 4.8-6.5). Survival analysis was undertaken in three separate groups based on mGPS score. In the mGPS 0 group the most highly predictive factors were performance status, weight loss, stage of NSCLC, and palliative treatment offered. In the mGPS 1 group performance status, stage of NSCLC, and radical treatment offered were significant. In the mGPS 2 group only performance status and weight loss were statistically significant. Discussion. This present study confirms previous work supporting the use of mGPS in predicting cancer survival; however, it goes fur...Continue Reading

References

Mar 10, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M L Janssen-HeijnenJ W Coebergh
Apr 3, 1999·British Journal of Cancer·R AbramovitchM Neeman
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Nov 9, 2004·Immunologic Research·Terry W Du Clos, Carolyn Mold
Dec 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul A GlarePatrick McMahon
Sep 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marco MaltoniUNKNOWN Steering Committee of the European Association for Palliative Care
Jan 25, 2007·International Journal of Colorectal Disease·Donald C McMillanColin S McArdle
Aug 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephan GrippReinhardt Willers
Nov 17, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K CannaA-M McNicol
May 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giorgio Vittorio ScagliottiDavid Gandara
Jan 22, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Andrea KochSverre Sörenson
Mar 26, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Donald C McMillan
Aug 7, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Anna L RichRichard B Hubbard
Sep 2, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa MartinVickie Baracos
Jan 25, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Derek GroseUNKNOWN Scottish Lung Cancer Forum
Mar 20, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Elaine Y L LeungDonald C McMillan
Apr 3, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Neil MacDonald
Aug 14, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Barry J LairdPal Klepstad

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