PMID: 1133682Jan 1, 1975

Simple and reliable method for serial sampling of blood from rats

Journal of Pharmaceutical Sciences
R A Upton

Abstract

A technique for serial sampling of whole blood, plasma, or serum from unanesthetized, unrestrained rats is described. This technique is sufficiently rapid, reliable, and independent of the need for elaborate preparation, specialized equipment, or practiced skills to appeal to a wide range of experimental and teaching situations requiring multiple sampling from many animals. A simple surgical procedure implants a one-piece jugular cannula cut from a commercial coil of silicone polymer tubing. Multiple blood samples are almost immediately available for 5 weeks or more. Plasma or serum samples are readily obtainable from each blood sample without transfer from the syringe in which it is collected. Intravenous injection through the cannula does not prejudice later sampling protocol.

Citations

Oct 1, 1983·European Journal of Drug Metabolism and Pharmacokinetics·M Dawson, T R Watson
Oct 1, 1983·European Journal of Drug Metabolism and Pharmacokinetics·R J Allan, T R Watson
Apr 1, 1987·European Journal of Drug Metabolism and Pharmacokinetics·A BarrowC M Walls
Mar 1, 1978·The International Journal of Applied Radiation and Isotopes·J W TriplettR B Smith
Jul 1, 1984·Physiology & Behavior·B C YoburnC E Inturrisi
Jul 1, 1980·Pharmacology, Biochemistry, and Behavior·K H DeTurck, W H Vogel
Sep 1, 1980·Pharmacology, Biochemistry, and Behavior·S PashkoW H Vogel
Jul 1, 1985·Pharmacology, Biochemistry, and Behavior·S T ConahanW H Vogel
Mar 1, 1981·Journal of Pharmacological Methods·J BazareJ F Young
Oct 1, 1994·Brain Research. Molecular Brain Research·D J EnnulatB M Cohen
Jul 1, 1993·Neurobiology of Aging·L MilakofskyW H Vogel
Feb 1, 1978·Pharmacological Research Communications·M J PattersonL B Jellett
Jul 31, 1999·General Pharmacology·C A TagliatiS Oga
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D P BaccanariT Spector
Oct 1, 1990·The Journal of Pharmacy and Pharmacology·Kohji NaoraK Iwamoto
Apr 8, 1998·The Journal of Pharmacy and Pharmacology·N NishimuraK Iwamoto
Jun 1, 1991·Antimicrobial Agents and Chemotherapy·T C BurnetteP De Miranda
Jun 1, 1980·The Journal of Clinical Investigation·P L BallardE C Jorgensen
Jun 20, 2001·Biological & Pharmaceutical Bulletin·T OgisoT Wada
Nov 1, 1991·Journal of Pharmacological Methods·P FrankE Burton
Nov 1, 1990·Journal of Pharmacological Methods·Z X Xu, S Melethil
Feb 1, 1992·Antimicrobial Agents and Chemotherapy·C U LambeD J Nelson
Dec 18, 2003·Drug Development and Industrial Pharmacy·Han-Gon ChoiChul-Soon Yong
Jul 23, 2009·Journal of Pharmacological and Toxicological Methods·Luka PeternelManica Cerne
Jun 30, 1984·Toxicology and Applied Pharmacology·T EndoT Murata
Oct 1, 1981·Food and Cosmetics Toxicology·R L Anderson
Dec 1, 1979·Food and Cosmetics Toxicology·F G Bartnik, F Wingen
Oct 1, 1989·The Journal of Pharmacy and Pharmacology·Y KatagiriK Iwamoto
Dec 1, 1988·The Journal of Pharmacy and Pharmacology·Y KatagiriK Iwamoto
Jul 11, 2006·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Makiko YoshidaKenji Matsuyama
Oct 1, 1979·Journal of Pharmacokinetics and Biopharmaceutics·L K Paalzow, P O Edlund
Dec 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·B E Dahlström, L K Paalzow
Apr 1, 1991·Journal of Pharmacokinetics and Biopharmaceutics·C J FuW D Mason
Jul 20, 1999·The Journal of Pharmacy and Pharmacology·Kohji NaoraK Iwamoto
Dec 18, 2001·Biopharmaceutics & Drug Disposition·J MifsudJ S Millership
Nov 23, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Amol A RajeKasim A Mookhtiar
Dec 1, 1990·Biopharmaceutics & Drug Disposition·J HirateS Nagase
May 1, 1989·Biopharmaceutics & Drug Disposition·J HirateC T Ueda
Jan 1, 1985·Acta Pharmacologica Et Toxicologica·P SjöbergL Plöen
Jan 1, 1977·Acta Pharmacologica Et Toxicologica·P O Edlumd, L K Paalzow
Mar 1, 1982·The Journal of Pharmacy and Pharmacology·K IwamotoJ Watanabe

Related Concepts

Carbon Radioisotopes
Catheterization
Centrifugation
Pharmaceutical Preparations
Hematocrit Procedure
Intravenous Injections

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.