Simple automated system for simultaneous production of 11C-labeled tracers by solid supported methylation

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Gemma QuincocesJosé Angel Richter

Abstract

We herein describe a simple setup for the automated simultaneous synthesis of L-[methyl-11C]methionine and N-[methyl-11C]choline by solid-supported methylation. The setup is extremely simple and easy to adapt to other automated systems and due to its versatility, the method can be utilized for the production of other radiopharmaceuticals requiring a simple [11C]methylation step. Furthermore, it can be used for multiple simultaneous synthesis.

References

Jul 1, 1979·The International Journal of Applied Radiation and Isotopes·G BergerD Comar
Jul 1, 1976·The International Journal of Applied Radiation and Isotopes·B Långström, H Lundqvist
Jan 1, 1976·European Journal of Nuclear Medicine·D ComarC Marazano
Jan 1, 1988·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·K IshiwataW Vaalburg
May 1, 1982·The International Journal of Applied Radiation and Isotopes·J DavisT F Budinger
Mar 10, 1999·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·T Hara, M Yuasa
Nov 1, 2000·Nuclear Medicine and Biology·A A WilsonS Houle
Apr 28, 2004·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·G ReischlH-J Machulla
Dec 21, 2004·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Markus MitterhauserKurt Kletter

❮ Previous
Next ❯

Citations

Jan 20, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Javier ArbizuJ A Richter
Dec 17, 2011·Nuclear Medicine and Biology·Filippo LodiStefano Boschi
Aug 6, 2010·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Gemma QuincocesIván Peñuelas
Dec 1, 2010·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Xia ShaoPeter J H Scott
Feb 26, 2010·European Journal of Radiology·W Wadsak, M Mitterhauser
Nov 10, 2015·Scientific Reports·Juan F Martín-RodríguezDavid A Cano
Nov 29, 2013·Journal of Labelled Compounds & Radiopharmaceuticals·Johannes Ermert, Heinz H Coenen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Man-ki Cheung, Chi-lai Ho
Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Markus MitterhauserKurt Kletter
Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
G ReischlH-J Machulla
Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
T Hara, M Yuasa
© 2022 Meta ULC. All rights reserved