Simple biochemical parameters and a novel score correlate with absence of fibrosis in patients with nonalcoholic fatty liver disease

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
Akash ShuklaShobna Bhatia

Abstract

Liver biopsy is the gold standard for detecting fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). Due to limitations of biopsy, various combinations of serum markers have been studied to predict liver fibrosis; many of these are patented and expensive, thereby restricting their evaluation. We prospectively evaluated the correlation of commonly used serum markers with fibrosis in Indian patients with NAFLD. Fifty-one patients (age 50.4 [SD 11.5] years) with biopsy-proven NAFLD underwent estimation of platelet count, total bilirubin, AST, ALT, serum albumin, γ-glutamyl transpeptidase (GGT), prothrombin time, serum cholesterol, triglycerides, α2-macroglobulin (A2M), apolipoprotein A1 (Apo A1), and haptoglobin. FIB-4, AST/platelet ratio index (APRI), and AST/ALT ratio were calculated and correlated with fibrosis (NAS-II score) on liver biopsy. Thirty-eight (74.5 %) patients had inflammation and 48 (94.1 %) had ballooning degeneration on histology; 29 had fibrosis, of whom 11 had ≥F2 fibrosis. High GGT (odds ratio [OR] 8.4 [1.85-38.10]; p = 0.007, area under the curve [AUROC] 0.65), low platelet count (OR 7.57 [1.83-31.45]; p = 0.001, AUROC 0.833), and low Apo A1 (OR 12.04 [2.98-47.3]; p = 0.0002, AUROC 0.76) were ...Continue Reading

References

Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P AnguloK D Lindor
Jun 2, 2000·Gastroenterology·V RatziuT Poynard
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
May 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vlad RatziuThierry Poynard
Oct 31, 2002·Gastroenterology·Arun J Sanyal, UNKNOWN American Gastroenterological Association
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
Dec 31, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael Charlton
Feb 11, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sylvie NaveauThierry Poynard
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard K SterlingUNKNOWN APRICOT Clinical Investigators
Nov 22, 2007·Digestive Diseases and Sciences·Deepak Kumar SinghShiv Kumar Sarin
Nov 27, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Indra Neil GuhaWilliam M Rosenberg
Nov 4, 2008·Journal of Hepatology·Paul CalèsFrançoise Lunel
Jun 16, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Amy G ShahUNKNOWN Nash Clinical Research Network
Jan 10, 2012·BMC Gastroenterology·Yoshio SumidaUNKNOWN Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD)
Nov 24, 2012·Acta Biochimica Et Biophysica Sinica·Weina WangMeiqing Feng

❮ Previous
Next ❯

Citations

May 5, 2020·Journal of Clinical Laboratory Analysis·Li-Kun ZhongHuai-Yu Song

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.