Simple chordates exhibit a proton-independent function of acid-sensing ion channels

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Tatjana CoricCecilia M Canessa

Abstract

Acid-sensing ion channels (ASICs) constitute a family of neuron-specific voltage-insensitive sodium channels gated by extracellular protons. Functions of ASICs in mammals include nociception, mechanosensation, and modulation of synaptic transmission. However, the role protons play in mediating the effects of ASICs remains elusive. We have examined ASICs from the ascidian Ciona intestinalis, a simple chordate organism whose nervous system in the larval stage exhibits high similarity to that of higher vertebrates. We found that the ascidian genome contains a single ASIC gene that gives rise to two splice forms analogous to the mammalian ASIC1 and ASIC2. CiASIC is expressed in most neurons of the larva but is absent in the adult. Despite high sequence similarity with mammalian counterparts, CiASIC is proton-insensitive when examined in heterologous systems or in larval neurons; the latter rules out the possibility that proton sensitivity is conferred by accessory proteins or particular factors present only in Ciona neurons. Down-regulation of the CiASIC transcript by double-stranded RNA disrupted the regular pattern of larval swimming, implying that proton-independent mechanisms mediate the effects of ASIC in vivo. Together the da...Continue Reading

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Citations

Oct 16, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Ewan St John Smith, Gary R Lewin
Apr 30, 2010·American Journal of Physiology. Cell Physiology·Tianbo LiCecilia M Canessa
Nov 9, 2012·American Journal of Physiology. Cell Physiology·Nobuyoshi KusamaChristopher J Benson
Jul 1, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hiroshi Q TerakuboKotaro Oka
Jan 15, 2015·Neuropharmacology·Stefan Gründer, Michael Pusch
Sep 24, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Luke A PattisonEwan St John Smith
Jul 19, 2017·Proceedings of the National Academy of Sciences of the United States of America·Yongbin LiXiao Liu
May 29, 2018·Nature Communications·Zhicheng ZuoEric B Gonzales
Jul 14, 2020·Frontiers in Cell and Developmental Biology·Kwantae KimAlberto Stolfi
Aug 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Timothy LynaghStephan A Pless

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