Simple coagulation tests improve survival prediction in patients with septic shock

Journal of Thrombosis and Haemostasis : JTH
G Lissalde-LavigneJ-C Gris

Abstract

Classic mortality prediction models in intensive care units (ICUs) are based on clinical scores, which do not contain any coagulation test (SAPS-II or SOFA scores). To determine whether coagulation tests can improve mortality prediction in patients with septic shock. One hundred fifty-eight consecutive patients with septic shock entering our institution's ICU were investigated on the first day of admission, and deaths were registered during the first month. Among all the coagulation tests performed, only the fibrinogen (Fg) plasma level, together with the SAPS-II score and the age, were included in our simplified mortality score [area under the receiver operating curve (AUC) 0.927, standard deviation (SD) 0.030], which was more efficient than SAPS-II and SOFA scores themselves in predicting first-week mortality, its optimized cut-off having a very high negative predictive value (NPV) [0.989; 95% confidence interval (CI) 0.967-1.000)]. A simplified score predicting first-month mortality, containing the prothrombin ratio and the antithrombin activity values in addition to the age, the hemoglobin concentration, and the SAPS-II and SOFA scores (AUC 0.889, SD 0.026), was found to be superior to the SAPS-II and SOFA scores, the optim...Continue Reading

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Citations

Jul 8, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Mirka SivulaAnne H Kuitunen
Sep 17, 2013·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Ning TangYingying Pan
Aug 30, 2013·The Cochrane Database of Systematic Reviews·Anne WikkelsøArash Afshari
Sep 12, 2018·British Journal of Haematology·Jean-Christophe GrisJean-Yves Lefrant
Jul 4, 2019·Internal and Emergency Medicine·Annalisa BoscoloPaolo Simioni
Feb 7, 2017·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Dunja MihajlovicGorana Mitic
Apr 17, 2019·Experimental and Therapeutic Medicine·Wenyan ZhouXigang Ma
Jan 26, 2021·International Journal of Clinical Practice·Concepción Beneyto-RipollMaría de Los Ángeles Carbonell-Torregrosa

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