PMID: 8589472Oct 1, 1995Paper

Simple equations for protein catabolic rate determination from pre dialysis and post dialysis blood urea nitrogen

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
L J GarredW G McCready

Abstract

Several simple equations exist for Kt/V determination from pre dialysis (Cpre) and post dialysis (Cpost) blood urea. However, comparable equations have not been available for calculation of protein catabolic rate (PCR), an essential parameter for assessing patient status. Three simple formulas for PCR determination were developed from the urea mass balance equation for an anuric patient in protein steady state receiving thrice weekly dialysis. The simplest formula, PCR = 0.0076 [Kt/V] [Cpre + Cpost] + 0.17 relates PCR (in g protein/kg/day) to Kt/V and pre and post dialysis blood urea nitrogen measurements (in mg urea nitrogen/dl) for the midweek session. When tested for 540 simulated patients spanning a range of Kt/V (0.6-1.6); PCR (0.6-1.6 g/kg/day); dialysis duration t (2-4 hrs) and interdialytic weight gain expressed as a percentage of dry body weight gained daily (0-4%), this equation yielded a maximum error of less than +/- 5%, within the accuracy generally required for clinical needs. A more accurate formula, [formula: see text] where Clm is the logarithmic mean of Cpre and Cpost, gave maximum errors in PCR estimation for the same 540 simulated patients of less than +/- 0.6%. Both formulas require a precise value of Kt/V....Continue Reading

Citations

Sep 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Donald RichardsonEric J Will
Sep 19, 2009·Néphrologie & thérapeutique·Bernard CanaudHélène Leray-Moragués
Apr 28, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E P BrassUNKNOWN CHIEF Investigators

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