PMID: 7082044Apr 1, 1982Paper

Simple estimate of creatinine clearance from plasma creatinine in neonates

Archives of Disease in Childhood
G ZacchelloF F Rubaltelli


Thirteen newborn infants, 8 preterm and 5 term, with either mild or serious neonatal asphyxia were studied. From the first 24 hours of life to day 13, glomerular filtration rate (GFR) estimated by creatinine clearance was compared with the values obtained using Schwartz's formula: GFR (ml/min per 1.73 m2) = 0.55 x length (cm)/plasma creatinine (mg/100 ml). Both in term and preterm infants, values of formula-calculated creatinine clearance were slightly higher than values obtained by the classical method; nevertheless the data show significant correlations, respectively r = 0.867 and r = 0.795 (P less than 0.001). This formula provides an adequate estimation of neonatal creatinine clearance (a marker for GFR) directly from plasma creatinine provided that body length is taken into consideration. The necessity for urine collection and the associated problems are thus obviated. The simplicity of Schwartz's formula permits easy monitoring of renal function, especially in neonatal asphyxia in which the risk of developing renal failure is great.


Jan 1, 1979·Biology of the Neonate·C L FawerJ P Guignard
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Jan 8, 1966·British Medical Journal·M K JosephM Kannankutty


Sep 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S NolteW Pringsheim
Jan 1, 1989·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·L P BrionG J Schwartz
Jan 1, 1989·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·G B Haycock
Sep 18, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Wael A SeliemAlison L Kent
Sep 7, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Katrina A FordMichael Burch
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Mar 12, 2004·Nephrology·Prayong VachvanichsanongAlan Geater
Oct 1, 1992·Archives of Disease in Childhood·B H Wilkins
Jun 1, 1997·Annals of Tropical Paediatrics·R A GbadegesinK Osinusi
Dec 12, 2020·KI Reports·Sofia PerazzoPatricio E Ray

Related Concepts

Asphyxia Neonatorum
Glomerular Filtration Rate
Neonatal Prematurity

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