Simple explanations before complex theories: Alternative interpretations of Sirotin and Das' observations

NeuroImage
Daniel A Handwerker, Peter Bandettini

Abstract

We make a few additional points regarding our discussion with Sirotin and Das' 2009 Nature paper and their 2011 NeuroImage response to our commentary. While we find their data interesting in itself, we remain concerned with how the data are interpreted by the authors. We discuss two categories of methodological issues that limit the conclusions one can draw from their results. (1) The measures of fit quality between the optical and electrical data: kernel shape variation, variance of predicted/measured signals, and R(2), interact with each other and are confounded by the fact that one condition has a lower signal magnitude and therefore, lower signal-to-noise-ratio (SNR). (2) Hemodynamic responses to distinct events will be incorrectly or inefficiently estimated if the hemodynamic responses overlap across periodic trials that are not jittered and have an inter-trial interval less than 15s. Most importantly, the overlapping responses across trials might cause transient effects that look similar to the anticipatory effects presented by Sirotin and Das. While their study demonstrates a potentially useful way to probe neurovascular coupling, we believe the current results have little practical relevance for interpreting hemodynamic...Continue Reading

References

Oct 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yevgeniy B SirotinAniruddha Das
Apr 22, 2010·NeuroImage·Daniel A Handwerker, Peter A Bandettini

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Citations

Jun 8, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tiffany HoJohn T Serences
Jun 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Miranda ScolariJohn T Serences
Feb 9, 2013·Brain Structure & Function·Barbara Heider, Ralph M Siegel
Aug 16, 2011·Neuropsychologia·John T Serences, Sameer Saproo
Oct 7, 2015·Frontiers in Human Neuroscience·Morgan NewhoffPeter N Steinmetz
May 23, 2014·NeuroImage·Kâmil Uludağ, Alard Roebroeck

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