Simple hamartoma of the retinal pigment epithelium with macular edema

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Austin BachTimothy G Murray

Abstract

Presumed congenital simple hamartoma of the retinal pigment epithelium (CSHRPE) is a rare intraocular finding that is described as a focal, nodular, jet black lesion. These lesions frequently occur at or near the macula and have no known association with changes in the surrounding neurosensory retina, retinal pigment epithelium, or choroid, nor have they been related with exudation or hemorrhage. Until now, there have been no cases reported of CSHRPE with associated vascular activity. A 14-year-old Hispanic adolescent girl with a presumed CSHRPE presented with adjacent macular edema. The patient was treated with an off-label intravitreal bevacizumab injection to decrease the edema. Two months later, the patient presented with improved visual acuity and decreased macular edema. This is the first documented case of macular edema secondary to vascular activity being associated with these rare lesions. When CSHRPE is found to have secondary vascular activity and associated macula edema, treatment of intravitreal bevacizumab may lead to improved visual and anatomical outcomes.

References

Dec 1, 1978·Archives of Ophthalmology·D Minckler, A W Allen
Jan 1, 1981·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·H Laqua
Feb 4, 1999·Archives of Ophthalmology·T W OlsenD M Albert
May 17, 2003·Ophthalmology·Carol L ShieldsJ Donald M Gass
Apr 30, 2005·American Journal of Ophthalmology·Dhananjay ShuklaRamasamy Kim
Jun 10, 2006·Journal of Pediatric Ophthalmology and Strabismus·Khaled SouissiAbdelhafidh Kraiem
Jul 21, 2009·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Indira M MadgulaMark Wescott
Apr 4, 2014·Seminars in Ophthalmology·Lorna W Grant, Rajeev K Seth

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Citations

May 11, 2017·Retinal Cases & Brief Reports·Parnian ArjmandCarol L Shields
Jun 26, 2021·Retinal Cases & Brief Reports·Sergio L G PimentelCarol L Shields

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