Abstract
We explored the relevance of simple markers (clinical or laboratory markers not requiring sophisticated laboratories) in the decision of initiation of therapy in resource-poor settings. Among HIV-infected Ethiopian cohort participants, simple markers predicting short-term death were examined using time-dependent Cox proportional hazards models. Timing of hypothetical treatment was compared between guidelines using the simple markers (based on presence of at least one marker), guidelines recommended by the United States Department of Health and Human Services (based on CD4 cell count and viral load), and guidelines for resource-limited settings recommended by the World Health Organization (WHO). From February 1997 to August 2001, 35 deaths were recorded among 155 HIV-positive participants. Simple independent predictors of death were low body mass index, HIV-related conditions, anaemia, and lymphocyte count < 1500 x 10(6)/l. In such time as was covered by our study, 135 (87%) of 155 cohort participants would have had the same management under both the simple markers and the DHHS guidelines, i.e., would have been treated (n = 114, 74%) or not treated (n = 21, 14%). Of the 114 participants hypothetically treated under either set of...Continue Reading
Citations
Dec 18, 2004·The Journal of Infection·Shui-Shan Lee, Ka-Hing Wong
Dec 29, 2005·AIDS Research and Human Retroviruses·Velia Ramírez-AmadorGabriela Anaya-Saavedra
Jan 16, 2013·The Journal of Infectious Diseases·Christopher R SudfeldWafaie W Fawzi
May 29, 2004·AIDS·Jean-Michel TassieDominique Legros
May 14, 2009·The Pediatric Infectious Disease Journal·Opemipo O JohnsonColeen K Cunningham
Jun 6, 2008·AIDS·Job C J CalisImelda Bates
Sep 5, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Philippa M MusokeLaura A Guay
Feb 20, 2007·HIV Medicine·S ShahC A Sabin
Jan 26, 2007·Journal of Clinical Microbiology·Workenesh AyeleGeorgios Pollakis
Dec 13, 2003·Archives of Disease in Childhood·E M MolyneuxM E Molyneux
Apr 15, 2011·AIDS Research and Treatment·Elijah Paintsil
Feb 21, 2013·Journal of the International Association of Providers of AIDS Care·H ByakwagaS Emery
Sep 5, 2006·BMC Infectious Diseases·Degu JereneBernt Lindtjørn
Oct 2, 2012·Journal of Postgraduate Medicine·I Shah, S Parikh
Jan 17, 2008·European Journal of Epidemiology·Pierre De BeaudrapEric Delaporte
Jun 4, 2005·American Journal of Public Health·Moïse DesvarieuxPierre-Marie Girard
Apr 1, 2008·Tropical Medicine & International Health : TM & IH·UNKNOWN ART-LINC Collaboration of International Databases to Evaluate AIDS (IeDEA)Matthias Egger
Dec 6, 2007·International Journal of Dermatology·Edith N NnorukaBen Anisuiba
Feb 26, 2010·Tropical Medicine & International Health : TM & IH·G MiiroH Grosskurth
Apr 25, 2006·Lancet·Laurent FerradiniChris Brasher
Dec 27, 2005·The Lancet Infectious Diseases·Robert ColebundersHarriet Mayanja-Kizza
Jul 18, 2015·Pathogens and Global Health·Loukia AketiMichel N Aloni
Sep 2, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Gil Cunha De SantisAlcyone Artioli Machado
Mar 6, 2012·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Annabelle J GourlayMaarten F Schim van der Loeff
Jan 1, 2005·Journal of the International AIDS Society·Degu Jerene, Bernt Lindtjørn
May 3, 2013·The American Journal of Clinical Nutrition·Christopher R SudfeldWafaie W Fawzi
Mar 2, 2005·International Journal of Epidemiology·C CostelloA Duerr
Jul 6, 2020·International Health·Amanda Marchionatti, Mariana Migliorini Parisi