Simple mathematical models do not accurately predict early SIV dynamics

Viruses
Cecilia NoeckerVitaly V Ganusov

Abstract

Upon infection of a new host, human immunodeficiency virus (HIV) replicates in the mucosal tissues and is generally undetectable in circulation for 1-2 weeks post-infection. Several interventions against HIV including vaccines and antiretroviral prophylaxis target virus replication at this earliest stage of infection. Mathematical models have been used to understand how HIV spreads from mucosal tissues systemically and what impact vaccination and/or antiretroviral prophylaxis has on viral eradication. Because predictions of such models have been rarely compared to experimental data, it remains unclear which processes included in these models are critical for predicting early HIV dynamics. Here we modified the "standard" mathematical model of HIV infection to include two populations of infected cells: cells that are actively producing the virus and cells that are transitioning into virus production mode. We evaluated the effects of several poorly known parameters on infection outcomes in this model and compared model predictions to experimental data on infection of non-human primates with variable doses of simian immunodifficiency virus (SIV). First, we found that the mode of virus production by infected cells (budding vs. burst...Continue Reading

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Citations

Apr 4, 2017·Epidemics·Bernhard P KonradDaniel Coombs
Apr 27, 2018·PLoS Computational Biology·Catherine M ByrneDaniel Coombs
Jul 20, 2018·Journal of Biological Dynamics·Fan BaiLinda J S Allen
Feb 16, 2016·FEBS Letters·Peter KumbergerFrederik Graw
May 27, 2016·Journal of Virology·Saikrishna GadhamsettyRob J de Boer
Sep 13, 2017·Frontiers in Immunology·Esteban A Hernandez-Vargas
Jan 8, 2021·Clinical Pharmacology and Therapeutics·Alan S Perelson, Ruian Ke
Jun 30, 2021·Journal of the Royal Society, Interface·Daniel B ReevesBryan T Mayer

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