Simple method for the determination of anthelmintic drugs in milk intended for human consumption using liquid chromatography-tandem mass spectrometry.

Journal of the Science of Food and Agriculture
Myriam Bustamante-RangelEncarnación Rodríguez-Gonzalo

Abstract

Helminth infections in animals to be consumed by humans are an important medical and public health problem. Pharmaceutical research has focused on developing new anthelmintic drugs for parasite control in these animals. However, the incorrect use of anthelmintics can leave residues in animal products intended for human consumption. Their determination is therefore crucial in terms of food safety. In this work, a simple and sensitive method has been developed for the analysis of anthelmintic drugs in milk. The method involves extraction of the analytes using a QuEChERS (quick, easy, cheap, effective, rugged, and safe) method, and separation and determination by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The use of a core-shell column significantly reduced the analysis time compared with conventional columns. The method was validated and applied to the analysis of different commercial milk samples: whole, semi-skimmed and skimmed cows' milk, and goats' milk. None of the benzimidazoles studied was found in the samples analyzed, so these were spiked with the analytes at three concentration levels (10, 50, and 100 μg kg-1 ). The proposed method provided high sensitivity compared with other methods for the determinati...Continue Reading

References

Aug 26, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Martin DanaherMichael O'Keeffe
Mar 31, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Didier OrtelliPatrick Edder
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Oct 17, 2012·Analytical and Bioanalytical Chemistry·Diego García-GómezRita Carabias-Martínez

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Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.