Simple Thermal Pretreatment Strategy to Tune Mechanical and Antifouling Properties of Zwitterionic Hydrogels

Langmuir : the ACS Journal of Surfaces and Colloids
Huacheng HeJiang Wu

Abstract

Zwitterionic hydrogels are promising biomaterials because of their high water content, three-dimensional network structure, and antifouling property. However, it still remains unclear about how mechanical properties of zwitterionic hydrogels affect their antifouling property. In this work, we propose a simple, thermal-pretreatment method to fabricate poly(sulfobetaine methacrylate) (pSBMA) hydrogels with varied mechanical properties that can be readily tuned by thermal pretreatment time and cross-linker density, as well as to correlate their mechanical property with antifouling property. The resulting thermal-treated pSBMA hydrogels show significantly enhanced mechanical properties with tunable compressive modulus and elastic modulus as compared to the untreated hydrogels. A combination of ELISA investigations and short-term cell adhesion assays also confirm that pSBMA hydrogels exhibit superior antifouling properties to resist protein adsorption and cell adhesion. Further analysis shows a linear inversion correlation between elastic modulus and protein adsorption of pSBMA hydrogels, i.e., the hydrogel with the higher elastic modulus exhibits the lower protein adsorption (the better antifouling property). This work not only pro...Continue Reading

References

Jan 1, 1989·Biochemical Pharmacology·D A HeroldD E Bruns
Jun 15, 2006·The Journal of Physical Chemistry. B·Zheng ZhangShaoyi Jiang
Dec 29, 2007·Seminars in Immunology·James M AndersonDavid T Chang
Aug 25, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Louisa CarrShaoyi Jiang
Nov 30, 2010·Biosensors & Bioelectronics·Wei YangShaoyi Jiang
Jan 27, 2011·The Journal of Physical Chemistry. a·Sriraj SrinivasanAndrew M Rappe
Jan 1, 2000·Biofouling·R F Brady, I L Singer
Jan 10, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Jiang Wu, Shengfu Chen
Apr 20, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Jiang WuYung Chang
May 15, 2012·Chemical Reviews·Marlène LejarsChristine Bressy
Jul 15, 2015·ACS Applied Materials & Interfaces·Chuan LengZhan Chen
Jan 29, 2016·ACS Applied Materials & Interfaces·Dianyu DongFanglian Yao
Jan 5, 2017·Biomaterials Science·Hsiu-Wen ChienWei-Bor Tsai
Apr 21, 2017·Science Translational Medicine·Nadine LohmannUwe Freudenberg
Oct 22, 2017·Trends in Biotechnology·Yu Shrike Zhang, Junjie Yao
Apr 28, 2018·ACS Applied Materials & Interfaces·Ranjithkumar RavichandranAnthony P F Turner
Aug 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Haiyan YinJian Ping Gong
Feb 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing ChangYanbin Huang
Jul 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hong ChenJie Zheng
Jun 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kang-Ting HuangChun-Jen Huang

❮ Previous
Next ❯

Citations

Feb 29, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sihang LiuShengfu Chen
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huacheng HeJiang Wu
Aug 14, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Zhongnan WangJianbin Luo
Sep 26, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Chengcheng ZhangZhan Chen
Dec 25, 2021·Frontiers in Bioengineering and Biotechnology·Zhoukun HeFei Deng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

© 2022 Meta ULC. All rights reserved