PMID: 15385834Sep 24, 2004Paper

Simplification of therapeutic drug monitoring for twice-daily regimens of lopinavir/ritonavir for HIV infection

Therapeutic Drug Monitoring
Christopher S AlexanderP Richard Harrigan

Abstract

Cost and inconvenience limit the application of full 12-hour pharmacokinetic (PK) analysis for routine therapeutic drug monitoring of antiretroviral medications. We explore whether lopinavir (LPV) and ritonavir (RTV) exposures can be estimated with limited sampling for patients taking twice-daily LPV/RTV. One hundred and one PK profiles from 81 patients, most receiving salvage therapies including twice-daily LPV/RTV, were obtained for the analysis. After a minimum of 2 weeks on a stable regimen, blood was drawn immediately before and at 1, 2, 4, 6, 8, 10, and 12 hours after a timed medication dose. Plasma drug concentrations were determined by a validated HPLC-MS-MS assay. Peak concentrations, evening troughs, and AUC0-12 h were entered into linear and log10-log10 linear regression models to determine the best correlation with LPV and RTV plasma concentrations using a maximum of 2 time points. The accuracy and precision of PK parameter estimates of the resultant models were tested on data collected for an additional 25 patients. Twelve models using various combinations of 2 timed LPV concentrations afforded accurate (maximum % bias = -6.45) and precise (relative standard deviation < 15%) estimates for the LPV peak concentration...Continue Reading

References

May 1, 2001·Clinical Pharmacokinetics·J Q TranB M Kerr
Mar 28, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Caroline SolasBruno Lacarelle
Apr 20, 2002·AIDS·Homayoun KhanlouCharles Farthing
May 22, 2002·Therapeutic Drug Monitoring·Rolf P G Van Heeswijk
Aug 17, 2002·Antimicrobial Agents and Chemotherapy·Bernard MasquelierUNKNOWN Groupe d' Epidémiologie Clinique du SIDA en Aquitaine
Jan 28, 2003·Therapeutic Drug Monitoring·David M BurgerUNKNOWN ATHENA Study Group
Mar 29, 2003·Drugs·Risto S Cvetkovic, Karen L Goa
Apr 2, 2003·The Journal of Antimicrobial Chemotherapy·David BurgerPeter Reiss

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Citations

Feb 8, 2011·Clinical Pharmacokinetics·Michael N Neely, Natella Y Rakhmanina
Jun 25, 2014·AIDS Research and Human Retroviruses·Guinevere Q LeeJeffrey N Martin
Jan 31, 2009·Journal of Clinical Pharmacology·Mark W HullJulio S G Montaner

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