Simplified 4-item criteria for polycystic ovary syndrome: A bridge too far?

Clinical Endocrinology
Inthrani R IndranEu Leong Yong

Abstract

Although the Rotterdam 2003 polycystic ovarian syndrome (PCOS) diagnostic criteria is widely used, the need to consider multiple variables makes it unwieldy in clinical practice. We propose a simplified PCOS criteria wherein diagnosis is made if two of the following three items were present: (i) oligomenorrhoea, (ii) anti-mullerian hormone (AMH) above threshold and/or (iii) hyperandrogenism defined as either testosterone above threshold and/or the presence of hirsutism. This prospective cross-sectional study consists of healthy women (n = 157) recruited at an annual hospital health screen for staff and volunteers from the university community, and a patient cohort (n = 174) comprising women referred for suspected PCOS. We used the healthy cohort to establish threshold values for serum testosterone, antral follicle counts (AFC), ovarian volume (OV) and AMH. Women from the patient cohort, classified as PCOS by simplified PCOS criteria, AMH alone and Rotterdam 2003, were compared with respect to prevalence of oligomenorrhoea, hyperandrogenism and metabolic indices. In healthy women, testosterone ≥1.89 nmol/L, AFC ≥22 follicles and OV ≥8.44 mL, best predicted oligomenorrhoea and were used as threshold values for PCOS criteria. An A...Continue Reading

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Citations

Jan 4, 2020·International Journal of Dermatology·Kabir SardanaGauri Vats
Dec 24, 2019·The Journal of Dermatological Treatment·Prekshi BansalGauri Vats
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Oct 13, 2020·Singapore Medical Journal·Ryan Wai Kheong LeeJerry Ky Chan
Sep 23, 2020·The Journal of Clinical Endocrinology and Metabolism·Ky'Era V ActkinsLea K Davis
Oct 21, 2020·Reproductive Biomedicine Online·Ragnheidur ValdimarsdottirInger Sundström Poromaa
Nov 4, 2020·International Journal of Molecular Sciences·Xianqin Qu, Richard Donnelly

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