Simplified and automatable radiochemical separation strategy for the production of radiopharmaceutical quality 86 Y using single column extraction chromatography

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Eduardo Aluicio-SarduyJonathan W Engle

Abstract

We present a simplified, automatable single-column radiochemical separation method using the extraction chromatographic branched-DGA resin for the production of no-carrier-added 86Y with a radiochemical yield higher than 95%, an apparent molar activity of 1.4 ± 0.4 Ci/μmol (DOTA) and 2.3 ± 0.7 Ci/μmol (DTPA), and a run-to-run recycling efficiency of the isotopically-enriched target of 98 ± 1%. These results enable the preparation of 86Y radiopharmaceuticals for 86Y/90Y-based cancer theranostic applications.

Citations

May 29, 2019·Journal of Labelled Compounds & Radiopharmaceuticals·Renata MikolajczakSuzanne E Lapi
Apr 10, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Lily LiChris Orvig
Jul 25, 2019·Scientific Reports·Eduardo Aluicio-SarduyJonathan W Engle
Jun 25, 2020·EJNMMI Radiopharmacy and Chemistry·Javad GarousiVladimir Tolmachev
Sep 10, 2020·Nuclear Medicine and Biology·Heinz H Coenen, Johannes Ermert
Apr 8, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Joseph J GrudzinskiJamey Weichert
Dec 22, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Reinier HernandezJamey P Weichert
Jul 1, 2021·Journal of the American Chemical Society·Aohan HuJustin J Wilson
Jul 21, 2021·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Rubel Chakravarty, Sudipta Chakraborty
Mar 24, 2020·Chemical Reviews·Weijun WeiWeibo Cai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.