Simplified HIV Testing and Treatment in China: Analysis of Mortality Rates Before and After a Structural Intervention

PLoS Medicine
Zunyou WuYu Wang

Abstract

Multistage stepwise HIV testing and treatment initiation procedures can result in lost opportunities to provide timely antiretroviral therapy (ART). Incomplete patient engagement along the continuum of HIV care translates into high levels of preventable mortality. We aimed to evaluate the ability of a simplified test and treat structural intervention to reduce mortality. In the "pre-intervention 2010" (from January 2010 to December 2010) and "pre-intervention 2011" (from January 2011 to December 2011) phases, patients who screened HIV-positive at health care facilities in Zhongshan and Pubei counties in Guangxi, China, followed the standard-of-care process. In the "post-intervention 2012" (from July 2012 to June 2013) and "post-intervention 2013" (from July 2013 to June 2014) phases, patients who screened HIV-positive at the same facilities were offered a simplified test and treat intervention, i.e., concurrent HIV confirmatory and CD4 testing and immediate initiation of ART, irrespective of CD4 count. Participants were followed for 6-18 mo until the end of their study phase period. Mortality rates in the pre-intervention and post-intervention phases were compared for all HIV cases and for treatment-eligible HIV cases. A total ...Continue Reading

References

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Citations

Dec 8, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ye MaZunyou Wu
Feb 21, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yan ZhaoJennifer M McGoogan
Dec 1, 2017·Journal of the International Association of Providers of AIDS Care·Kelly A HennesseyJean W Pape
Apr 18, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Jie WuLin Sun
Mar 6, 2019·Journal of the International Association of Providers of AIDS Care·Yan ZhaoZunyou Wu
Jun 21, 2019·Drug Discoveries & Therapeutics·Qi Tang, Hongzhou Lu
Dec 23, 2019·The Journal of Antimicrobial Chemotherapy·Antonella d'Arminio MonforteUNKNOWN Icona Foundation Study Group
May 18, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yan ZhaoJulio S G Montaner
Nov 22, 2017·Tropical Medicine & International Health : TM & IH·Jacob BorTill Bärnighausen
Nov 21, 2018·Emerging Infectious Diseases·Xiaohong PanZunyou Wu
Aug 30, 2017·AIDS and Behavior·Ngai Sze WongHuifang Xu

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Methods Mentioned

BETA
ELISA

Software Mentioned

TEMPRANO
SAS

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