PMID: 3759338Jun 1, 1986Paper

Simplified procedure for carrying out simultaneous multiple hydrogen fluoride cleavages of protected peptide resins

International Journal of Peptide and Protein Research
R A HoughtenC J Kirby

Abstract

Methods have recently been presented which greatly increase the ability to synthesize large numbers of peptides. These advances make it essential to be able to cleave large numbers of protected peptide resins. Two different procedures are presented for carrying out cleavage of protected peptide resins. The first procedure enables multiple cleavages to be carried out with many existing HF apparatuses, while the second utilizes a new apparatus design. Using these procedures, at least 50 individual cleavages can be carried out per day.

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Citations

Jul 30, 1993·International Journal of Cancer. Journal International Du Cancer·G Reinholdsson-LjunggrenH G Ljunggren
Apr 1, 1993·International Journal of Peptide and Protein Research·M PohlH Höcker
Feb 23, 1996·The Journal of Biological Chemistry·E Pérez-PayáS E Blondelle
Jan 23, 1999·The Journal of Peptide Research : Official Journal of the American Peptide Society·V KrsmanovicM T Hearn
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Jan 23, 1999·The Journal of Peptide Research : Official Journal of the American Peptide Society·J R AppelC Pinilla
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Apr 25, 2008·Current Protocols in Immunology·C PinillaR A Houghten
Jul 17, 2018·Current Medicinal Chemistry·Annamaria SandomenicoMenotti Ruvo
Feb 23, 1996·The Journal of Biological Chemistry·S E BlondelleE Pérez-Payá
Sep 1, 1996·Journal of Molecular Recognition : JMR·E Pérez-PayáS E Blondelle
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Nov 30, 2012·Journal of Peptide Science : an Official Publication of the European Peptide Society·Reena GyandaChristopher J Armishaw
May 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luis J CruzCarl G Figdor
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