Simplified Quantification and Acquisition Protocol for 123 I-MIBG Dynamic SPECT

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Jing WuChi Liu

Abstract

Previous studies have demonstrated the feasibility of absolute quantification of dynamic 123I-metaiodobenzylguanidine (123I-MIBG) SPECT imaging in humans. This work reports a simplified quantification method for dynamic 123I-MIBG SPECT using practical protocols with shortened acquisition time and voxel-by-voxel parametric imaging. Methods: Twelve healthy human volunteers underwent five 15-min dynamic SPECT scans at 0, 15, 90, 120, and 180 min after 123I-MIBG injection. List-mode SPECT data were binned into 29 frames and reconstructed with corrections for attenuation, scatter, and decay. Population-based blood-to-plasma correction and metabolite correction were applied to the image-derived input function. Likelihood estimation in graphical analysis (LEGA) was used as a simplified model to obtain volume of distribution (VT) values, which were compared with those obtained with the reversible 2-tissue (2T) compartment model. Three simplified protocols were evaluated with 2T and LEGA using a 30-min scan started simultaneously with tracer injection plus a 15-min scan at 90, 120, or 180 min after injection. Voxel-by-voxel LEGA fitting was applied to the aligned dynamic images using both the full protocol (five 15-min scans) and the si...Continue Reading

References

Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J LoganS J Gatley
Dec 10, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ramin V ParseyJ John Mann
Mar 25, 2009·Cardiology Clinics·Mark I Travin
Dec 8, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ji ChenErnest V Garcia
Jun 7, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Berlinda J van der VeenMarcel P M Stokkel
Sep 27, 2014·Physics in Medicine and Biology·Chung ChanChi Liu
Jan 30, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Adrien LebasnierDenis Agostini
Apr 4, 2015·PloS One·Birk Diedenhofen, Jochen Musch
Jun 3, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kenichi Nakajima, Tomoaki Nakata
Jun 3, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Aukelien C Dimitriu-LeenArnold F Jacobson
Jun 13, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jagat NarulaArnold F Jacobson
Apr 16, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jing WuChi Liu
Jan 4, 2017·IEEE Transactions on Nuclear Science·P Hendrik PretoriusMichael A King
May 14, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Hironori YamamotoMasatake Fukunami

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Citations

Aug 1, 2018·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·David S Goldstein, William P Cheshire
Feb 7, 2019·Physics in Medicine and Biology·Jing Wu, Chi Liu
May 18, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jing WuChi Liu

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