Abstract
In clinical trials of potential pharmacotherapies for cocaine addiction, objective determination of subject relapse relies on qualitative urine analysis for benzoylecgonine, the major metabolite of cocaine. Unlike qualitative analysis, quantitative measurement allows differentiation between continued cocaine use and a single use, as well as identification of changes in the quantity of cocaine used at different times. The only quantitative technique that has been used is expensive and not generally feasible. This study was performed to modify an existing qualitative technique for use as a new simple and readily available quantitative method for identifying cocaine use among research subjects. Benzoylecgonine levels in 24-hour urine specimens collected from 11 cocaine-addicted subjects hospitalized in a research setting were measured semi-quantitatively by fluorescence polarization immunoassay. Accurate results required thorough mixing of urine specimens prior to analysis. At admission, eight subjects had urinary benzoylecgonine levels > or = 0.30 microgram/ml, the standard positive/negative cut-off used in qualitative analysis. The mean half-life of benzoylecgonine during initial elimination was 0.46 +/- 0.08 (SEM, n = 8) days. ...Continue Reading
References
Nov 1, 1992·Archives of General Psychiatry·S S O'MalleyB Rounsaville
Jan 1, 1991·Journal of Analytical Toxicology·J J AmbreT I Ruo
Mar 1, 1989·Journal of Analytical Toxicology·E J Cone, W W Weddington
Dec 1, 1988·The American Journal of Medicine·R D Weiss, F H Gawin
Nov 1, 1988·Journal of Analytical Toxicology·J AmbreS Belknap
Jun 1, 1988·Forensic Science International : Synergy·E J ConeJ Mitchell
Sep 1, 1987·Journal of Analytical Toxicology·A Poklis
Dec 1, 1987·Annals of Internal Medicine
Nov 1, 1985·Journal of Analytical Toxicology·J Ambre
Dec 1, 1969·The Journal of Pharmacy and Pharmacology·F Fish, W D Wilson
Jan 1, 1984·Journal of Analytical Toxicology·J AmbreT I Ruo
Aug 1, 1993·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·A ToyosakaY Tomimoto
May 1, 1993·Journal of Analytical Toxicology·F MartinezR R Watson
Jul 1, 1993·Journal of Analytical Toxicology·C L WinekJ A Feldman
Jan 1, 1993·Journal of Analytical Toxicology·R Schwarzhoff, J T Cody
Jun 1, 1996·Drug and Alcohol Dependence·S L BatkiR T Jones