Simplified rat lung transplantation by using a modified cuff technique

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
Wei ZhaiWalter Weder

Abstract

Mizuta's cuff technique in rat lung transplantation (LT) model has some disadvantages, such as twisting of blood vessels or bronchus and being time-consuming, which complicate procedures for anastomosis. This study was performed to investigate the advantage of using a simplified cuff technique in LT. The anastomosis time was compared in two groups. In group I, Mizuta'scuff technique was performed in 50 rat orthotopic left lung transplants. In group II, a simple modified cuff technique was performed in 48 rat orthotopic left lung transplants. The successful rate of the new technique for anastomosis was 100%. No twist of vessels or bronchus and no bleeding or air leakage were observed in group II. The anastomosis time of group II was significantly less than for group I (11.2 +/- 2.1 min vs. 18.1 +/- 3.6 min, mean +/- SD, p < .01). This simple modified cuff technique led to less anastomosis time and avoided potential complications induced by the cuff-tail technique. It has been verified to be a safe, simple, and reproducible technique that can provide us with a more precise assessment in the rat LT model.

References

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Citations

Jan 9, 2013·European Journal of Medical Research·Haizhou GuoKe Jiang
Jul 31, 2013·The Journal of Surgical Research·Yukio TsushimaWolfgang Jungraithmayr
Jun 5, 2013·The Journal of Surgical Research·Andreas HabertheuerDominik Wiedemann
Jan 15, 2013·The Annals of Thoracic Surgery·Barbara V ErneIlhan Inci
Nov 22, 2011·Transplantation Proceedings·S De VleeschauwerG Verleden
Feb 3, 2009·The Journal of Thoracic and Cardiovascular Surgery·Wolfgang M JungraithmayrWalter Weder
Jun 5, 2016·Archivos de bronconeumología·Daniel Ruiz-PérezFrancisco García-Río
Jun 30, 2009·Surgery Today·Ryujiro SugimotoKenneth R McCurry
Apr 27, 2018·World Journal of Transplantation·Taufiek Konrad Rajab
Oct 15, 2019·Experimental Lung Research·Taufiek Konrad Rajab

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