Simplified risk stratification for pulmonary arterial hypertension associated with connective tissue disease

Clinical Rheumatology
Xiaodi LiQiang Wang

Abstract

To explore the long-term prognostic value of a simplified risk assessment strategy based on the 2015 European Society of Cardiology (ESC)/European Respiratory Society (ERS) pulmonary hypertension (PH) guidelines in Chinese patients with connective tissue disease (CTD) associated with pulmonary arterial hypertension (PAH). We identified 50 CTD-PAH patients diagnosed by right heart catheterization. A retrospective chart review was completed to assess their clinical presentation and laboratory test results. A simplified version of the risk stratification model proposed by the 2015 ESC/ERS PH guidelines was applied, which included the WHO functional class, the 6-minute walking distance test, N-terminal pro-B-type natriuretic peptide plasma levels, pericardial effusion, right atrial pressure (RAP), cardiac index (CI), and mixed venous oxygen saturation (SvO2). The risk grades were defined as follows: low risk = at least 3 low-risk variables and no high-risk variables; high risk = at least 2 high-risk variables, including SvO2 or CI; and intermediate risk = when the above definitions of low or high risk were not fulfilled. The study endpoint was 3-year all-cause mortality. Twenty patients were defined as a low-risk group, while 30 we...Continue Reading

References

Oct 1, 1996·British Journal of Rheumatology·E T KohM Abu-Shakra
May 15, 2002·Annals of the Rheumatic Diseases·C VitaliUNKNOWN European Study Group on Classification Criteria for Sjögren's Syndrome
Oct 22, 2008·American Journal of Respiratory and Critical Care Medicine·Robin CondliffeJ Gerry Coghlan
May 6, 2014·The European Respiratory Journal·Yan-Jie HaoZhuo-Li Zhang

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Citations

Jun 9, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Kazuhiko NakayamaNoriaki Emoto

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