Simplifying cardiovascular risk estimation using resting heart rate

European Heart Journal
Marie Therese CooneyI M Graham

Abstract

Elevated resting heart rate (RHR) is a known, independent cardiovascular (CV) risk factor, but is not included in risk estimation systems, including Systematic COronary Risk Evaluation (SCORE). We aimed to derive risk estimation systems including RHR as an extra variable and assess the value of this addition. The National FINRISK study (including 14,997 men and 15,861 women) was used to derive two formulas for estimation of 10 year risk of CV disease (CVD) mortality. The first formula contained current SCORE variables-total cholesterol, systolic blood pressure, smoking, age and gender. Inclusion of RHR resulted in only minor improvements in discrimination, based on both area under receiver operating characteristic curve (AUROC, men: 0.840 from 0.838, P = 0.5038; women: 0.87 from 0.865, P = 0.0522) and net reclassification index (NRI). The second, simplified formula contained only, age, smoking, gender, and body mass index. Addition of RHR to this simplified formula resulted in a statistically significant and meaningful improvement in AUROC (men: 0.819 from 0.812, P = 0.037; women: 0.862 from 0.827, P = 0.023) and NRI (0.05). Calibration also improved. A simple chart for estimating 10 year risk of fatal CVD including RHR is pres...Continue Reading

References

Jun 1, 1987·American Heart Journal·W B KannelL A Cupples
Apr 6, 2000·International Journal of Epidemiology·E VartiainenP Puska
Jun 6, 2003·European Heart Journal·R M ConroyUNKNOWN SCORE project group
Jul 5, 2006·Annals of Internal Medicine·Nancy R CookPaul M Ridker
Sep 27, 2006·European Heart Journal·Stéphane CookOtto M Hess
Dec 22, 2006·The New England Journal of Medicine·Thomas J WangRamachandran S Vasan
Aug 28, 2007·Journal of the American College of Cardiology·Kim FoxUNKNOWN Heart Rate Working Group
Jun 25, 2008·BMJ : British Medical Journal·Julia Hippisley-CoxPeter Brindle
Feb 6, 2009·BMJ : British Medical Journal·Judith HsiaUNKNOWN Women's Health Initiative Research Group
Jul 18, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Marie Therese CooneyUNKNOWN SCORE Investigators

❮ Previous
Next ❯

Citations

Jan 11, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Karl WerdanUrsula Müller-Werdan
Sep 15, 2010·Current Hypertension Reports·Marie Therese CooneyIan M Graham
Nov 15, 2013·Archives of Disease in Childhood·Helen PetersLeah Li
Feb 2, 2013·Transplantation Research·Jose Jg De LimaFlavio J de Paula
Mar 29, 2011·Journal of Women's Health·Matthew A AllisonMaurizio Trevisan
Jul 30, 2011·Pacing and Clinical Electrophysiology : PACE·Udi NussinovitchNaomi Nussinovitch
Jun 8, 2011·European Journal of Clinical Investigation·Sanne A E PetersMichiel L Bots
Oct 16, 2010·Journal of the American College of Cardiology·Raimund ErbelUNKNOWN Heinz Nixdorf Recall Study Investigative Group
Jan 12, 2013·International Journal of Cardiology·Remy H H BemelmansUNKNOWN SMARTStudy Group
Jul 20, 2012·European Journal of Preventive Cardiology·Guy De BackerMarie-Therese Cooney
May 4, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Renate B SchnabelEmelia J Benjamin
Nov 6, 2015·Circulation. Cardiovascular Genetics·Allan LinnebergLise Lotte N Husemoen
Jun 19, 2021·Journal of the American College of Cardiology·Ian M GrahamUNKNOWN European Society of Cardiology Cardiovascular Risk Collaboration
Feb 7, 2016·Central European Journal of Public Health·Vitali Gorenoi, Anja Hagen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.